Clinical Outcome of Induction Chemotherapy and Simultaneous Chemo Radiotherapy in Stage IIIA or IIIB Inoperable Non-Small Cell Lung Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Aims: Two meta-analyses have shown a survival advantage for the addition of concurrent chemotherapy to radiotherapy and other sequential radiochemotherapy in the treatment of inoperable advanced lung cancer. The aims of this study were to examine treatment outcomes (survival, time to progression, response rates and toxicity) in patients with lung cancer treated with sequential chemor adiation and to compare these with outcomes in patients treated with radiation alone. Materials and Methods; Between December 2010 and November 2012, 138 patients of inoperable Stage 111A and Stage 111B Non small Cell lung cancer (NSCLC) were treated with chemoradiation.. Acute toxicity was recorded, with toxicity graded using the common toxicity criteria version4. The median age was 58 years. All patients were staged with computed tomography and brnchoscopy. After induction chemotherapy 68 patients were treated with radiation alone and 70 patients were treated concurrent chemo radiation. This was due to waiting list problems. The chemotherapy used was paclitaxel 60 mg/m2 weekly with radiotherapy, (the neo adjuvant dose was Paclitaxel 175 mg/m2 with cisplatin 75 mg/m2 3 weekly). External beam radiotherapy was given to the chest (40 Gy/20 fractions/4 weeks) followed by 10 Gy boost in 5 fractions. Results: Patients benefited to an extent of 3.6 months of median time to progression and 3.42 months of mean survival time without major increases in toxicity. The frequent toxicity in our study was Grade 1 Esophagitis followed by grade 1 pneumonitis Conclusion: There was a trend towards improved survival with concurrent chemoradiation in this cohort of patients that may become significant with longer follow-up
Authors and Affiliations
Dr Preeya. V
Keywords
Related Articles
- EP ID EP527058
- DOI -
- Views 61
- Downloads 0
Ice Pack Application on the Level of Pain in Episiotomy Wound
True experimental design with Quantitative approach was used to assess the effectiveness of ice pack application on the level of pain in episiotomy wound among postnatal mothers reveals that the ice pack application was...
Continuous Epidural Infusion of 0.125% Bupivacaine for Pain Relief in Labour: A Comparison with Intermittent Top up of 0.25% Bupivacaine
Background: Pain is a noxious and unpleasant stimulus which produces fear, discomfort, untold suffering and reflex activity. One of the most distressing variety of pain experienced by mankind is labourpain. Obstetric ana...
A Clinico-Epidemiological Study of Acute Diarrhoea in Under Five Children Admitted in a Tertiary Care Hospital in Western Maharashtra
Background: Diarrhoea has been defined in many ways, as an increased water content of stools, altered consistency, increased frequency or combinations of all these three. A lot has been studied regarding diarrhoea which...
Clinical Presentation of Neck Space Abscess and its Management in a Rural Based Tertiary Care Centre
Objective: The aim of this study is to evaluate patients of neck abscess in respect to its common presentation, predisposing factors, co-morbidity, frequently involved area and treatment modality needed. Study Design: It...
Study of Sympathetic Autonomic Functions in Stage 1 Essential Hypertensive Subjects
Background: Essential hypertension may have a cause but our knowledge is not enough to recognize it. The sympathetic nervous system helps to control circulation. Increased incidence of tachycardia, arrhythmias in hyperte...