CLINICAL PROFILE AND RISK FACTORS OF MAJOR INFECTIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 35
Abstract
BACKGROUND Infection is a major source of morbidity and mortality in patients with Systemic Lupus Erythematosus (SLE). Prevalence of infections in SLE is much higher than in general population. Infection remains the most important practical problem while managing lupus patients, especially in developing countries. There are only few studies on clinical profile and risk factors of infections in SLE. MATERIALS AND METHODS This is a descriptive study. Hospitalised SLE patients with infections were examined for pattern of infections in SLE and they were compared with SLE patients without infections for demographic and the lupus related variables. RESULTS 105 infection related admissions were compared with 118 infection unrelated admissions. A causative organism was identified in 79.6%. The pattern of infections was as follows: Gram negative infections (54.4%), fungal infections (24.4%), tuberculosis (8.8%) and gram-positive infections in 12.2%. Higher disease activity was seen in the infected group. The duration of prednisolone intake and hence the cumulative prednisolone dose prior to infection was significantly higher in infected group. Infection rate was not higher in the subgroup, which received other immunosuppressive drugs. The incidence of leukopenia and lupus nephritis was same in both groups. CONCLUSION Infections were common in SLE patients, especially in younger age and early part of the illness. Infections were associated with prolonged use of steroids and higher disease activity.
Authors and Affiliations
Nambiar Veettil Jayachandran, Liza Rajasekhar, Gumdal Narsimulu
Keywords
Related Articles
- EP ID EP544843
- DOI 10.14260/jemds/2018/866
- Views 78
- Downloads 0
UNILATERAL AXILLARY MASS - AN UNUSUAL PRESENTATION OF FILARIASIS
Filariasis is a major parasitic infection, which continues to be a public health problem in India with most infections being caused by Wuchereria bancrofti. The area of lymphatic involvement and duration of inf...
A PROSPECTIVE STUDY OF LAPAROSCOPIC CHOLECYSTECTOMY VERSUS OPEN CHOLECYSTECTOMY IN PATIENTS WITH CHOLECYSTITIS
BACKGROUND Cholelithiasis is one of the major causes of morbidity, particularly in females. Most of the cases of cholelithiasis are silent. Cholecystectomy is the choice of treatment in symptomatic cholelithiasis. With t...
PRK – PHOTO REFRACTIVE KERATECTOMY IN CORRECTION OF MYOPIA: HOW USEFUL IS IT?
The study comprised of retrospective and prospective evaluation of 30 eyes treated with PRK – Photo Refractive Keratectomy at Mahatme Eye Bank Eye Hospital, Nagpur India. Our results show that PRK is less saf...
A 20 YEARS’ EXPERIENCE ON GRANULOSA CELL TUMOUR
BACKGROUND The prognostic factors and the recurrent nature of Granulosa cell tumour is unclear. Chemotherapy has a compelling role in locally advanced cases, inoperable cases and metastatic cases. This retrospective stud...
CONGENITAL AGENESIS OF GALLBLADDER- A HOSPITAL-BASED STUDY
BACKGROUND Embryologically, gallbladder is developed from pars cystic of ventral duodenal bud. During its rotation in clockwise direction towards dorsal bud, it fails to give rise to develop gallbladder or its different...