Clinical profile and role of serum globulin in assessment of immunity in patients with HIV
Journal Title: Medpulse International Journal of Medicine - Year 2018, Vol 6, Issue 2
Abstract
Background: India has the third largest epidemic in the world with 2.1 million people living with HIV. Along with T helper cell dysfunction, there is documented evidence of B cell dysfunction. B cell dysfunction is associated with Objectives: This study was done to evaluate correlation between serum globulins and CD4 count, and role of serum globulins as a marker for immunity. Materials and Methods: This study was done in Kamineni academy of medical sciences and research centre, data was collected from 47 patients and analyzed. RESULTS AND DISCUSSION- most common presentation was anemia (29.7%), 25% had tuberculosis,17% had oral candidiasis, pneumonia and gastroenteritis. Serum globulins had negative correlation with CD4. Serum globulin >3.5 gm/dl had 65% sensitivity and 73% specificity, 72% positive predictive value in predicting CD4 count less than 200cells/cumm. CONCLUSIONFuture studies to evaluate the potential use of calculated globulins as marker for immunity during follow up in patients being treated with ART are warranted.
Authors and Affiliations
Suresh I, Sai Krishna Tulasi, M Swamy
Keywords
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