CLINICAL PROFILE AND SHORT-TERM OUTCOME OF ACUTE NEPHRITIC SYNDROME IN CHILDREN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 88
Abstract
BACKGROUND Glomerulonephritis generally presents as a constellation of findings that includes haematuria, proteinuria and oedema. Poststreptococcal glomerulonephritis is the commonest form of acute glomerulonephritis in developing countries. Objectives1. To study the clinical profile of acute glomerulonephritis. 2. To study the different clinical laboratory parameters at admission and at 8 weeks of onset of illness. MATERIAL AND METHODS This is a prospective, descriptive study conducted in a tertiary care teaching hospital in South India from January 2016-December 2016. Data regarding the clinical features, laboratory parameters, treatment were collected. All these patients were further followed up at 8 weeks and descriptive analysis done. RESULTS The most common cause of glomerulonephritis in the study group was poststreptococcal glomerulonephritis (42.9%) followed by drug-induced nephropathy (28.6%). The most common complaints were haematuria, facial puffiness, decreased urine output and oedema. Hypertension was found only in 14.3% of study group. 4.8% of patients had nephrotic range of proteinuria. The most common infection preceding was Pyoderma (61.5%) in case of PSGN. High ASO titre was seen commonly with pharyngitis. 45.2% patients had decreased Serum C3 at diagnosis. All the patients were treated conservatively. At 8 weeks followup, haematuria was persisting in 28.6% patients. Only 2 patients had persistently low serum C3 and single patient had high creatinine. CONCLUSION Post-streptococcal glomerulonephritis is still the most common cause of glomerulonephritis in children followed by drug-induced nephropathy. The changing epidemiology needs to be followed up regarding the need for NSAID use and guidelines to restrict its use in any form to absolute indications only.
Authors and Affiliations
Surya Kandashamparambil Kamalakarababu, Ansu Sam, Sajini Varghese
Keywords
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- EP ID EP277917
- DOI 10.14260/jemds/2017/1337
- Views 93
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