CLINICAL PROFILE OF DOWN SYNDROME IN CHILDREN LESS THAN 14 YEARS IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 24
Abstract
BACKGROUND Down syndrome is the most common and most easily recognised condition causing intellectual disability. Down syndrome occurs in 1 in 700 to 1 in 1000 live births. The aim of this study was to evaluate the incidence and clinical profile of Down syndrome in children below 14 years. MATERIALS AND METHODS Children below 14 years who presented with symptoms of Down syndrome from 1st December 2015 to 30th November 2017 were included in this hospital-based case series study. RESULTS The hospital-based incidence was found to be 0.1%. The mean age of presentation was found to be 28.6 months. The ratio of male: female was 1.57. The mean maternal age at delivery was found to be 27.6 years. About 9.5% of Down syndromes were diagnosed antenatally. The first order children were more common (42.9%) followed by second order (32.5%). Diagnosis by using Hall’s criteria was done in 94.4% cases. On karyotyping 94.4% had non-disjunction and 4.6% patient had translocation. CONCLUSION The chromosomal non-disjunction was the most common type of chromosomal abnormality in Down syndrome. Down syndrome is associated with significant systemic abnormalities and is not infrequent among mothers younger than 25 years of age. Early diagnosis and proper screening should be undertaken among these patients.
Authors and Affiliations
Leena Das, Mangal Charan Murmu, Satyapriya Sahoo
Keywords
Related Articles
- EP ID EP450570
- DOI 10.14260/jemds/2018/648
- Views 74
- Downloads 0
CLINICAL BEHAVIOR OF UTERINE CERVICAL CARCINOMA IN AN IMMUNOCOMPROMISED RENAL TRANSPLANT RECIPIENT WITH LITERATURE ON THE INCIDENCE, PATHOGENESIS AND CLINICAL BEHAVIOR
Incidence of malignancy is 2-31% in patients who had renal transplant. Due to advances in immunosuppression the incidence of graft versus host reaction and rejection of transplant are rare. Due to increase in...
MANAGEMENT OF ACUTE ANTERIOR INFERIOR DISLOCATION OF SHOULDER BY MILCH METHOD AT MIMS, MANDYA: A RETROSPECTIVE STUDY
BACKGROUND Acute anterior inferior dislocation of shoulder is a common orthopaedic emergency affecting up to 60% of all major joint dislocation. 1-5 , most common is anterior inferior type. 6-7 ; variety of...
COMPARISON OF SUPRAGLOTTIC AIRWAY DEVICE I-GEL WITH CLASSIC LARYNGEAL MASK AIRWAY AND PROSEAL LARYNGEAL MASK AIRWAY FOR SHORT SURGICAL PROCEDURES
BACKGROUND Supraglottic airways are airway devices for providing ventilation, oxygenation and anaesthetic gases to the patients. The SGA has revolutionised airway management because of its ease of insertion, hands-free o...
DRY EYE IN PRESENT SCENARIO
PURPOSE To compare which test modality is better and less time consuming for diagnosis of dry eye. MATERIAL AND METHOD The present study was conducted on 100 subjects in Department of Ophthalmology, Index Medica...
PREVALENCE OF CONSTITUTIVE AND INDUCIBLE CLINDAMYCIN RESISTANCE AMONG CLINICAL ISOLATES OF STAPH AUREUS IN KASHMIR VALLEY: A HOSPITAL BASED STUDY
Methicillin resistant Staphylococcus aureus has become endemic in India with the prevalence ranging from 25% in the west India to 50% in south India. Clindamycin therapy is a useful alternative to treatment of su...