Clinical Profile of Leptospirosis in Khammam
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 10
Abstract
BACKGROUND: In the last few decades infectious diseases like leptospirosis have re-emerged and are on the rise. With other infectious diseases like Malaria, Dengue, Infective hepatitis which simulate leptospirosis being rampant, there is a need to know the clinical profile, complications of leptospirosis particularly from this part of the country. OBJECTIVES: The present study was undertaken to understand the clinical profile, laboratory findings and complications of leptospirosis. METHODS: Fifty patients who were positive for IgM anti leptospiral antibodies in Mamata General Hospital were subjected to detailed history, clinical examination, investigations and followed up till discharge or death. They were treated as per protocol, clinical data was tabulated. Statistical analysis was done. RESULTS: Dark Ground Microscopy of urine was positive for leptospira in 58% patients. The age groupcommonly involved was 20-39 years(58%). Most of the patients were males (76%), with occupation involving outdoor activity(66%). Common symptoms encountered were fever, musculoskeletal, jaundice and oliguria. Less commonly seen were bleeding, gastrointestinal symptoms, respiratory symptoms and altered sensorium. Important signs seen were conjunctival suffusion, hepatomegaly, hypotension, splenomegaly. Hyperbilurubinemia was predominantly of conjugated type and elevation of transminases was mild to moderate. Mean bilurubin was 4.67mg/dl. Mean SGOT was 99.23U/L and SGPT was 96.97U/L. AKI was seen in 46% and six of them needed Hemodialysis. Thrombocytopenia was seen in 56% patients.40% had multiorgan failure, 4% had aseptic meningitis, 2% had ARDS, 2% had GI hemorrhage. CONCLUSION; A high degree of clinical suspicion is the key to diagnosis ofleptospirosis. Fever and musculoskeletal features are most common symptoms. Conjunctival suffusion is a common finding. Liver and kidney are common organs involved. Multi Organ Failure was significantly associated with mortality (p<.05). Thrombocytopenia was significantly related to clinical bleeding (p<.001)
Authors and Affiliations
Venkatesh Garlapati
Keywords
Related Articles
- EP ID EP212491
- DOI -
- Views 60
- Downloads 0
Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation
Background: Direct laryngoscopy and endotracheal intubation are potent stimuli that initiate a hemodynamic response leading to increase in heart rate and blood pressure. This response can be attenuated by appropriate pre...
Fibro-osseous Lesions of Cranio-facial region: An Institutional Study
Introduction: Fibro-osseous lesions are a diverse group of bone disorders with fibrous dysplasia and ossifying fibroma as the major entities. They are extremely slow growing tumors that share overlapping clinical, radiog...
Post Traumatic Disability among Patients with Head Injury in a Tertiary Care Centre
Background: Traumatic Brain injury, according to the World Health Organization, will surpass many diseases as a major health problem and leading cause of disability by the year 2020.It can have far reaching consequences...
GPU Based Rician Noise Removal in MR Images Using Fast Gradient Projection Algorithm
This paper presents a combined Fast Gradient Projection Method with Gabor filter technique for removing the Rician noise present in MR images using general purpose Graphics Processing Units (GPUs) and MATLAB. In this wor...
Comparative study between Manual Liquid Based Cervical Cytology and Conventional Smear in Peri Menopausal and Post Menopausal Women
Objective: Aim of this study is to compare the conventional Pap smears with manual liquid based cervical cytology in peri menopausal and post menopausal women. Method: A prospective study of 70 women was carried out in S...