CLINICAL PROFILE OF VOGT-KOYANAGI-HARADA SYNDROME IN A TERTIARY EYE CARE CENTRE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 70
Abstract
BACKGROUND Vogt-Koyanagi-Harada syndrome is a granulomatous panuveitis with multisystemic manifestations. It is characterised by exudative retinal detachments, cutaneous and neurological manifestations. The main aim of this study is to document the epidemiological features, diverse clinical manifestations, angiographic and optical coherence tomography and characteristics of VKH disease. MATERIALS AND METHODS 20 patients who were diagnosed as Vogt-Koyanagi-Harada syndrome were included in the study after applying appropriate inclusion and exclusion criteria were included in the study. RESULTS 20 patients were included in the study, which included 18 females (90%) and 2 males (10%). The mean age of the study population was 39.21 years. All patients presented with complaints of defective vision, 17 patients (85%) had bilateral loss of vision and 3 patients (15%) had unilateral defective vision. One patient (5%) had poliosis and vitiligo and one patient (5%) had alopecia. The mean Best Corrected Visual Acuity (BCVA) at presentation was 1.33 LogMAR units. The mean post-treatment BCVA was 0.28 LogMAR units. The improvement in visual acuity following treatment was found to be statistically significant with a ‘p’ value <0.05. 17 patients (85%) presented with bilateral exudative retinal detachment. 26 eyes (70.27%) showed extensive exudative retinal detachment. 10 eyes (27.02%) showed multifocal exudative retinal detachment. All patients were treated with systemic corticosteroids resulting in decrease in inflammation and resolution of exudative retinal detachments. Patients whose inflammation was refractory to systemic corticosteroids were treated with immunosuppressants, namely azathioprine (1 patient, 5%). CONCLUSION In summary, Vogt-Koyanagi-Harada disease is a bilateral, diffuse, granulomatous uveitis associated with vitiligo, poliosis, alopecia, central nervous system and auditory signs, which responds to appropriate systemic steroid therapy.
Authors and Affiliations
Latha Hariharan, Arthi Mohankumar
Keywords
Related Articles
- EP ID EP277849
- DOI 10.18410/jebmh/2017/834
- Views 65
- Downloads 0
TUBERCULOUS LUPUS OF NOSE: INTERESTING PRESENTATION INVOLVING FATHER AND SON
Cutaneous tuberculosis, although a disease of the past, is occasionally seen especially in the developing world. It can present in at least seven morphological types. 1 Lupus vulgaris is the commonest morphological prese...
ASSOCIATION OF ELEVATED CARDIAC BIOMARKERS WITH MORTALITY AFTER ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
BACKGROUND Cardiovascular disease is commonly seen in patients with Chronic Obstructive Pulmonary Disease (COPD). Brain Natriuretic Peptide (BNP) is a marker of ventricular dysfunction and troponin T of myocardial necros...
A PROSPECTIVE STUDY OF COMPARISON BETWEEN ADDITIONS OF INTRAVENOUS INFUSION VERSUS EPIDURAL INTRATHECAL DEXMEDETOMIDINE WITH ROPIVACAINE FOR LOWER ABDOMINAL SURGERY
BACKGROUND Dexmedetomidine is a centrally acting active selective α2A agonist, which is used as an adjunct to anaesthesia, analgesia and sedation are produced with little respiratory depression, amnesia or anaesthesia. R...
PTERYGIUM EXCISION IN COMPARISON OF BARE SCLERA TECHNIQUE AND CONJUCTIVAL AUTOGRAFT
INTRODUCTION: Pterygium is a degenerative condition of the subconjuctival tissue which proliferates as vascularized granulation tissue to invade the cornea, destroying the superficial layers of the stroma and bowmans mem...
A STUDY ON COLOUR VISION DEFICIENCY AMONG MEDICAL STUDENTS OF ODISHA
BACKGROUND Normal human beings are trichromates and can appreciate three primary colours which are red, green and blue. The inability to appreciate colour properly is known as colour blindness or colour vision deficiency...