CLINICAL RELEVANCE OF COEXISTENCE OF DUCTAL CA IN SITU AND INVASIVE DUCTAL CARCINOMA OF BREAST
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 47
Abstract
BACKGROUND There are many studies reported in the literature with respect to the Ductal Carcinoma in Situ (DCIS) progressing into Invasive Ductal Carcinoma (IDC) of the breast. However, there is hardly any study on the coexistence of both and its clinical significance. The aim of the study is to analyse the clinical and pathological parameters of synchronous DCIS and IDC to predict the prognostic factors. MATERIALS AND METHODS 42 patients with a final pathological diagnosis of synchronous DCIS and IDC diagnosed in 2009-11 were included in the study. Statistical analysis was done using SPSS software utilising the appropriate analytical methods. RESULTS Majority of the patients in this study group presented with early breast cancer (64.3%). Forty eight percent were Her2 subtype (ER, PR negative and HER2/neu-positive) and 31% were triple negative. Eighty one percent of the IDC associated histology was Not Otherwise Specified (NOS) type. Grade 3 lesions were more common (57%). Recurrence of the disease occurred in 66% of patients during a mean duration of follow up of 3.6 years with predominance of visceral metastasis (51.5%). Recurrence was more common in node positive disease (59.5%), those with lymphovascular emboli (59.5%) and perinodal spread (76%) on histopathological examination. CONCLUSION Synchronous DCIS and IDC disease entity appears to have an aggressive nature compared to the course of IDC alone entity. Prognostic factors relating to IDC appears to correlate well with recurrence than that of the prognostic factors of DCIS component in such synchronous setting.
Authors and Affiliations
Kirithiga Ramalingam, Krishnamurthy Swamyvelu
Keywords
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- EP ID EP220015
- DOI 10.18410/jebmh/2017/563
- Views 97
- Downloads 0
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