Clinical significance of apoptotic index in non-smell cell lung cancer
Journal Title: Współczesna Onkologia - Year 2005, Vol 9, Issue 9
Abstract
Apoptosis remains a physiological form of cell death, which enables elimination of damaged cells. Apoptosis is also called programmed cell death, because this process is exactly regulated by several genes including P53, BCL2 and BAX. p53 protein and bax activate apoptosis, whereas bcl-2 protein inhibits the process of programmed cell death. p53 protein activates apoptosis in response to cell injury and its proapoptotic function might be inhibited by mdm2 protein, which forms with p53 the autoregulatory feed-back loop. Additionally, a close correlation between mdm2-pRb explains how the two most important tumor suppressor genes P53 and RB cooperate in p53 depending activation of apoptosis. It seems that RB has an antiapoptotic activity, because in cells in which the function of RB was lost, apoptosis was activated due to healthy P53 gene. Disturbances in the function of tumor suppressors genes and activation of protooncogenes could result in cancer development. Proper regulation of apoptosis enables keeping a balance between cell death and proliferation. Instead of apoptosis, the cell can die due to necrosis. Apoptosis of the tumor cells was usually assessed with the use of the TUNEL technique. In current literature, the prognostic value of occurrence of apoptotic cells in lung cancer remains controversial. In this paper the author presented the clinical significance of the apoptotic index in non-small cell lung cancer
Authors and Affiliations
Dorota Dworakowska
Keywords
Related Articles
- EP ID EP101922
- DOI -
- Views 45
- Downloads 0
Rak jelita grubego – chemioterapia adjuwantowa i zaawansowanych postaci z zastosowaniem cetuximabu samego i w skojarzeniu z cytostatykami
Rak jelita grubego jest poważnym wyzwaniem dla współczesnej onkologii. Rocznie stwierdza się 875 tys. nowych przypadków tej choroby, a umiera 570 tys. osób. Populacja dotknięta rakiem jelita grubego to mieszkańcy wysoko...
Leki cytostatyczne i ich kancerogenność – problem zagrożenia zawodowego personelu medycznego
Wiele leków cytostatycznych wykazuje działanie mutagenne, teratogenne oraz kancerogenne. Dla leków tych niemożliwe jest określenie bezpiecznego poziomu ekspozycji. Stanowi to ryzyko dla personelu medycznego zajmującego s...
Squamous cell carcinoma antigen (SCC) in diagnostics and monitoring treatment of patients with cervical cancer
Squamous cell carcinoma antigen (SCC) is the first marker of squamous cell carcinoma and a member of the serin proteinase inhibitor family. Increased concentration of SCC occurs in squamous cancers of the region of the h...
High-dose chemotherapy supported with autologous hematopoietic stem cell transplant in small-cell lung cancer
Small-cell lung cancer provides clinicians with a paradox. Although it is a highly chemosensitive disease, it remains ultimately fatal for the majority of patients. The majority of patients respond to first-line chemothe...
Effectiveness evaluation of hemibody irradiation as palliative treatment of patients with multiple painful bone dissemination
Effectiveness of hemibody irradiation (HBI) of 61 patients with multiple painful bone dissemination treated between 2001-2004 was evaluated. 21 patients had UHBI and 40 LHBI. Pain intensity on an 11-degree scale, pain fr...