Clinical Significance of Signet Ring Cell Histology in Colorectal Malignancies
Journal Title: International Journal of Anatomy Radiology and Surgery - Year 2017, Vol 6, Issue 1
Abstract
Introduction: Signet Ring Cell Carcinoma (SRC) is a histological variant of adenocarcinoma. SRC accounts for 0.5 to 1% of all colorectal malignancies. SRC usually occurs at an early age compared to usual adenocarcinoma. Lymph nodal and peritoneal spread is common and occurs early in the course of colorectal SRC. Aim: To study clinical significance of signet ring cell histology in colorectal carcinoma. Materials and Methods: We retrospectively studied 209 cases of colorectal adenocarcinoma in our institute from Jan-2012 to July-2015. All patients in the study were evaluated with colonoscopy except for those presented with intestinal obstruction, as they were taken up for emergency laparotomy. Age and sex of the patients, stage of the disease, segment of the large bowel involved, management and outcomes were studied. Results: Of 209 patients included in the study, 11 were found to have SRC variant of adenocarcinoma. Out of 198 patients with adenocarcinoma (non-signet ring cell), 111 were male and 87 were female, Out of 11 patients with SRC, 6 were male and 5 were female. Median age of patients with adenocarcinoma is 57 years, while it is 48 years in SRC group. Out of 198 patients with adeno carcinoma, 112 patients underwent surgery of which 7 were palliative procedures, while 9 out 11 patients underwent surgical intervention in SRC group, of which 6 patients underwent palliative procedures Conclusion: This study signifies that colorectal SRC carcinomas have early age of onset. Advanced stage at the time of presentation and low rates of curative resection due to peritoneal and mesenteric lymph nodal deposits, which contributed to high mortality in colorectal signet ring cell carcinomas.
Authors and Affiliations
Dr. Revanth Maramreddy, Ashfaque Mohammed, Karunakar Reddy Chalimidi, Jyothi Kini, Pulla Reddy Seelam
Keywords
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- EP ID EP328977
- DOI 10.7860/IJARS/2017/24003:2229
- Views 165
- Downloads 0
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