Clinical significance of Yes-associated protein 1 in esophageal squamous cell carcinoma
Journal Title: 中国临床医学（Chinese Journal of Clinical Medicine） - Year 2024, Vol 31, Issue 5
Abstract
ObjectiveTo explore the expression and clinical significance of Yes-associated protein 1 (YAP1) in esophageal squamous cell carcinoma. MethodsImmunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carcinoma. The differences of YAP1 expression and clinical parameters were analyzed between YAP1 positive group and YAP1 negative group. Kaplan-Meier curve was used to analyze the influence of YAP1 expression on survival of patients. ResultsThe positive rate of YAP1 in esophageal squamous cell carcinoma was 30.52%. The tumor invasion was deeper in YAP1 positive group (Pï¼0.001). Kaplan-Meier survival analysis showed that YAP1 positive patients had longer disease-free survival (DFS) and overall survival (OS) among patients surviving longer than 30 months (Pï¼0.05). The multivariate Cox regression analysis showed that the invasion depth of tumor was an independent factor affecting DFS (HRï¼1.371, 95%CI 0.993-1.894, Pï¼0.035) and OS (HRï¼1.489, 95%CI 1.066-2.080, Pï¼0.020). ConclusionsYAP1 has a certain percentage of positive rate in esophageal squamous cell carcinoma; for patients with survival longer than 30 months, YAP1 positive indicates a better prognosis.
Authors and Affiliations
Kun LIU,Yingying GUAN,Dongxian JIANG,Huijuan XU,Yingyong HOU,Jun HOU,
Keywords
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