Clinical Spectrum of Severe Plasmodium falciparum Malaria in a Tertiary Care Centre of Eastern India
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2016, Vol 12, Issue 4
Abstract
Introduction: Plasmodium falciparum malaria is one of the major public health problem presented with varied clinical severity. This study was carried out to observe the clinical spectrum of severe falciparum malaria in a tertiary health care centre. Methods: This study was undertaken in hospitalized adults with suspected severe malaria. Confirmation of falciparum infection was done by ICT/QBC and single-step-PCR. Diagnosis of severe malaria was done by WHO- guideline 2010. Results: 450 adult cases with falciparum infection were studied. Maximum number of cases was from 15-25 years age group depicting the high exposure to malaria. In these patients, acute renal failure (ARF) was the most common (36.2%) complication followed by cerebral malaria (35.3%), jaundice (27.8%), hepatic dysfunction (21.8%), respiratory distress (18.4%), severe malarial anemia (15.8%), thrombocytopenia (15.1%), and hypoglycemia (9.3%). Mortality was found in 6.0% of cases. Cerebral involvement and ARF were the common cause of death in these patients. Conclusion: ARF is the most common type of clinical severity followed by cerebral malaria in adults and both are equally responsible for death along with other complications. Looking into the matter of varied clinical severity, accurate diagnosis, effective anti-malarial treatment along with supportive therapy is necessary to triumph over this deadly severe falciparum malaria.
Authors and Affiliations
Prasanta Purohit, Pradeep Kumar Mohanty, Siris Patel, Snehadhini Dehury, Satyabrata Meher, Kishalaya Das, Ashutosh Rath, Jagannath Hati, Ashok Kumar Behera
Malaria Parasite and Anaemia Prevalence in Adult HIV-patients Attending Care and Treatment Centre in Baptist Hospital Mutengene, Cameroon
Aim: This study was aimed at investigating malaria parasite and anaemia prevalence, the impact of co-infection on immune-haematological parameters, clinical/treatment profiles and how malaria preventive measure associate...
Prevalence of Malaria and Co-infection with Human Immuno-Deficiency Virus (HIV) in Selected Areas of Ondo State, Nigeria
The prevalence of malaria and its co-infection with Human Immunodeficiency Virus (HIV) was investigated in Owena, Idanre Local Government Area and State Hospital Akure, Ondo State, Nigeria. A total of 150 blood samples (...
Urban–Rural Disparities and Determinants of Nutritional Status of Under-Five Children: An Example of Akinyele Local Government Area, Ibadan
Background: Nutrition is an important element of a child’s survival and development. To achieve MDG 4 in Nigeria, nutritional status of under-five children needs to be improved as malnutrition remains an underlying facto...
Prevalence and Risk Factors for Placental Malaria in Nnewi, South East Nigeria
Background: Placental malaria is one of the complications of malaria in pregnancy and is associated with poor pregnancy outcome. Demonstration of its prevalence and risk factors will help in modifying the measures in the...
Clinical Profile of Patients with Scorpion Sting
Introduction: Scorpion sting is a major public health problem in developing countries, especially in villagers. Manifestations include vomiting, profuse sweating, piloerection, diarrhoea, loss of appetite, loss of sphinc...