Clinical study of molecular hormonal receptor level status among carcinoma of breast in Karaikal population
Journal Title: International Archives of Integrated Medicine - Year 2017, Vol 4, Issue 10
Abstract
Background: Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for metastases (for example, lymph node status and histological grade) fail to classify accurately breast tumors according to their clinical behavior. The discordance in estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) status between primary and recurrent breast cancer are being intensively investigated and a large amount of data have been produced. Aim: To study the epidemiological and clinical profile of carcinoma breast with analysis of receptor status. Materials and methods: A descriptive study of 40 cases of carcinoma breast with receptor analysis, in Vinayaka Missions Medical College, Karaikal, from June 2015- June 2016 was done. Detailed history, clinical examination, and investigations were done, after staging, patients were treated with a suitable type of mastectomy, chemotherapy, radiotherapy and hormonal therapy as indicated. Cases were followed up for one year, data thus obtained was analyzed and results compared. Results: All our cases were unilateral- 26 (65%) right breast and 14(35%) left breast. Majority of the cases had lump measuring >5cm –30 (75%). 23 (57.5%) of cases had a tumor in the upper outer quadrant, followed by other locations. Most of the cases were stage III- 27 (67.5%), 3 (7.5%) had metastasis at the time of presentation. The predominant histological type was infiltrating ductal carcinoma 31 (77.5%). There was a predominance of ER+/PR+24 ( 60%), followed by ER-/PR-, ER+/PR- then ER-/PR+. Conclusion: Majority of the cases belonged to stage III, with a predominance of infiltrating ductal carcinoma. Reporting to the hospital in earlier stages of the disease is lacking in the study population and highlights the need for public education and screening methods. It also emphasizes to analyze hormone receptor status in patients, as receptor positive status significantly reduces recurrence if hormone therapy is initiated.
Authors and Affiliations
M Balasundaram, Reny Jayaparakas, Subith P Bhaskar
Keywords
Related Articles
- EP ID EP410798
- DOI -
- Views 124
- Downloads 0
Current and Future Perspectives for Dentin-pulp Tissue Engineering - An update
The ball has been set rolling with the isolation of dental pulp stem cells in 2000 for tissue engineering to generate dental pulp. The rationale lies in the possibility of further root development and reinforcement of de...
Effect of Body Mass Index (BMI) on Peak Expiratory Flow Rate in young adults
Background: Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”....
A Comparative Evaluation of Intranasal Dexmedetomidine and Intranasal Midazolam for Premedication in Pediatric Surgery
Background: We sought to compare the effects of intranasal Dexmedetomidine a more selective alpha 2 receptor with the effects of Midazolam administered via the same route Materials and methods: After approval by hospita...
Functional and radiological outcome in non-operative versus operative management of fracture clavicle
Background: Clavicle fractures are one of the most common bone injuries seen in adult population. Generally all the fracture clavicles were treated non-surgically by figure-eight bandage and surgical intervention like pl...
A study of factors influencing the duration of stay in forensic psychiatric ward patients
Background: Psychiatric patients who are admitted in to forensic psychiatric ward have frequent hospital admissions and prolonged length of hospital stay, may be due to the growing demands in health services and the lim...