Clinical Value of Neutrophil/Lymphocyte Ratio in Predicting Postoperative Complications and Prognosis in Patients with Colorectal Cancer Undergoing Surgical Treatment
Journal Title: Turkish Journal of Colorectal Disease - Year 2020, Vol 30, Issue 1
Abstract
Aim: Recently, the preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). In this context, the preoperative neutrophil/lymphocyte ratio (NLR) has been proposed as a useful predictor of prognosis. In this study, we aimed to determine the clinical value and prognostic significance of neutrophil/lymphocyte ratio in predicting postoperative complications in patients undergoing surgical treatment for colorectal cancer. Method: Patients who underwent surgical treatment for colorectal cancer between 2015-2019 were included in the study. group 1 (Low NLR) and group 2 (High NLR) were formed. Demographic and clinical characteristics, intraoperative and postoperative results, and mean survival were compared. The value of NLR in predicting postoperative complications at the determined cut-off value was examined. Results: Patients were divided into two groups according to the cut-off value of 2.08. Group 1 consisted of 56 patients, and group 2 consisted of 223 patients. Male sex was dominant in both groups (60% vs 64%, p=0.349), while patients in group 2 received more neoadjuvant treatment (29.1% vs 12.5%, p=0.007). Intraoperative complication rates were similar (1.8% vs 4%, p=0.369), pathological grade (p=0.031), and stage (p=0.113) were similar. Postoperative complications were more common in group 2 (24.7% vs 10.7%, p=0.015). Total survival was shorter in group 2 (46 months vs. 52 months, p=0.025). At the determined cutoff value, NLR predicted postoperative complications with 22.94% specificity and 90.6% sensitivity. Conclusion: High NLR was associated with postoperative complications and survival. Although it has a prognostic value, its value in predicting postoperative complications is limited and cannot be used alone.
Authors and Affiliations
Orçun Yalav, Uğur Topal, Ayşe Gizem Ünal, İsmail Cem Eray, Ahmet Rencüzoğulları
Keywords
Related Articles
- EP ID EP684924
- DOI 10.4274/tjcd.galenos.2020.2019-11-5
- Views 180
- Downloads 0
Melanosis Coli: Case Report
Melanosis coli is an incidental benign finding characterized by the deposition of dark brown pigment in the colonic mucosa. The cause of this situation is due to long-term laxative use. We report a female patient who und...
What is the Role of the Neutrophil: Lymphocyte Ratio in Colorectal Cancer?
The composition and cell-to-cell interactions of the peripheral immune compartment are known to influence outcomes in multiple disease entities, both neoplastic and otherwise. There is an ongoing search for a reliable bi...
Approach to Appendiceal Masses Due to Acute Appendicitis: Analysis of 126 Cases
Aim: This study aimed to present our clinical approach in patients with clinical manifestations of delayed appendicitis and appendiceal mass. Method: Data of 126 patients with appendiceal mass and admitted to our clinic...
Duration of the Sypmtoms Influence the Outcome after Botulinum Toxin Injection in Anal Fissure
Aim: To assess the effect of duration of the symptoms on outcome after botulinum toxin injection in anal fissure treatment. Method: Data of the patients who underwent botulinum toxin injection for chronic anal fissur we...
Unexpected Histopathological Diagnoses in Acute Appendicitis Specimens: A Retrospective Analysis of 2076 Patients
Aim: Acute appendicitis is the most common cause of emergency abdominal surgery in the world. Although the etiology of appendicitis is still not fully known, possible causes include lumen obstruction. Fecaloid and lympho...