Clinico-Hematological Profile in Dengue: A Tertiary Care Institutional Study
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 1
Abstract
Introduction: Dengue is the most important arthropod borne viral infection of humans. As there is an alarming rise in Dengue Fever and its complications (i.e, Dengue Hemorrhagic Fever/Dengue Shock Syndrome), rapid and accurate diagnosis is of paramount importance. Aims/Objectives: 1. To study the prevalence of dengue in different age groups and sex distribution. 2. To study the spectrum of clinical symptomatology in endemic population. 3. To evaluate the clinical, hematological, biochemical, serological and coagulation profile in different stages of confirmed Dengue cases. 4. To correlate clinical, hematological, biochemical, serological and coagulation findings with disease severity and clinical outcome. Methods: A prospective study from June 2014 to June 2015 was done among 100 serologically confirmed cases of dengue by rapid immunologic tests. Evaluation of clinical data, hematological and biochemical parameters with peripheral smear study were carried out. Results: A total of 100 serologically positive cases were studied with adults (63%) and children (37%). The commonest clinical presentation was fever (100%), headache (80%), retroorbital pain (48%), vomiting (18%), myalgia (64%), arthralgia (52%), hemorrhagic manifestation (18%) and shock (06%). The Hematological profile observed were decrease in Hemoglobin (62.5%), Hemoconcentration (35%), Leukopenia (57.5%) with presence of atypical lymphocytes (43.7%). and Thrombocytopenia of varying degree (62%). Liver enzymes were elevated in 25 % of cases and markedly elevated APTT level in 18% of cases of DHF/DSS. Conclusion: Early and prompt diagnosis by rapid diagnostic kits along with clinical features and serial measurements of hematological and biochemical parameters helps in reducing the morbidity and mortality associated with Dengue.
Authors and Affiliations
N. Prasanna
Keywords
Related Articles
- EP ID EP462137
- DOI 10.21088/ijprp.2278.148X.6117.12
- Views 114
- Downloads 0
Analysis of Cervical Pap Smears and Its Utilty in Screening for Premalignant Lesions in a Tertiary Care Instituition
Introduction: Cervical cancer is the leading cause of mortality and morbidity among women with nearly four lakh new cases diagnosed annually worldwide, of which 80 % cases are in developing nations. Cervical Pap smear is...
Glycated Hemoglobin [HbA1C] As a Dual Marker for Glycemic Status and Dyslipidemia in Diabetics: A Cross Sectional Analysis of 450 Cases
Background: The prevalence of dyslipidemia in diabetes mellitus [DM] is 95%. Diabetic patients with accompanied dyslipidemia are soft targets of cardiovascular deaths. Glycated Hemoglobin [HbA1C] the gold standard for as...
FNAC of Head and Neck Lesions in Paediatric Age Group
Introduction: Fine Needle Aspiration Cytology is well established diagnostic procedure for the head and neck region. It is simple and rapid procedure. Most common head and neck lesions in paediatric age group are of infl...
A Correlation of Cytomorphology and Acid Fast Bacilli Positivity in Tuberculous Lymphadenopathy: It’s Importance in Resource Poor Countries
Background: Tuberculous lymphadenitis is one of common cause of peripheral lymphadenopathy in developing countries. Fine needle aspiration cytology (FNAC) is important tool in early detection and can be further supported...
Detection of Micrometastasis in Lymph Nodes in Various Malignancies Using Immunohistochemical Marker (CK7)
Introduction: Carcinoma from almost all the organs has a tendency for regional metastasis. Nodal status is a key prognostic indicator in such patients, particularly with N0 stage. Occult metastasis in the form of microme...