Clinico-Hematological Study of Megaloblastic Anemia and Associated Megakaryocytic Alterations
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 2
Abstract
Context: Megaloblastic anemias are hematological disorders in which nuclear maturation lags behind the cytoplasmic maturation. Thrombocytopenia in megaloblastic anemia is because of ineffective thrombopoiesis in some studies and hypoproduction in some studies. Objective was to study the spectrum of clinicohematological features in megaloblastic anemia & comparative bone marrow aspiration study ofthrombocytopenia secondary to megaloblastic anemia due to hyper-destruction or hypoproduction. Aims: To understand the clinico-hematological spectrum of Megaloblastic anemia and associated megakaryocytic alterations. Methods and Material:100 cases of thrombocytopenia were included in the study. Bone marrow findings in 35 cases ofthrombocytopenia of megaloblastic etiology was compared with 40 cases of marrow proven hypo productive thrombocytopeniaand 25 cases of hyper destructive thrombocytopenia. Results: Most common age group presenting with megaloblastic anemia was 20-30 years,with M:F ratio 1.4:1. Most common complaints were fatigue and generalised weakness. 14.28% of patients had shown normal in number of megakaryocytes, 57.14% of patients had shown increased number 28.57% had shown decrease in number of megakaryocytes. Dysplastic megakaryocytes were seen in 43.75%, 26.25% & 30% of cases of megaloblastic anemia, acute leukaemia and immune thrombocytopenic purpura respectively. Conclusions: Both hypoproduction and ineffective thrombopoiesis are the underlyingmechanisms in megaloblastic thrombocytopenia as evidenced by marrow findings. We conclude that megaloblastic thrombocytopenia is to be included as separate category apart from hypo proliferative and hyper destructive groups. The presence of dysplastic megakaryocyte should not prompt interpretation of myelodysplastic syndromes and should always be correlated with patient’s clinico hematological parameter.
Authors and Affiliations
Manikantaswamy Marisetty
Keywords
Related Articles
- EP ID EP595772
- DOI 10.21088/ijprp.2278.148X.8219.9
- Views 58
- Downloads 0
ABO and Rhesus Blood Group Distribution among Blood Donors from Rural based Medical College & Hospital at Warudi, Jalna (Maharashtra) India
Background: The red blood cell surface has a system of antigens on them which constitute the Blood group system. Blood Group is an inherited trait in Mendelian fashion; there are 33 well defined blood group systems. But...
Corelation between Mean Platelet Volume and Platelet Count: An Extensive Study in 500 Healthy Adult Population
Introduction: Platelet plays an important role in atherosclerosis, the major cause of unstable coronary syndromes. Despite an increasing volume of literature which suggests that platelet volume measurement might be usefu...
Histopathological Study of Tumours of Epidermis and Epidermal Appendages
Introduction: Skin is a complicated protective covering [1]. It is divided into two seemingly separate but functionally interdependent layers, i.e., epidermis and dermis. Adnexae extend from epidermis into the dermis and...
Analysis of FNAC in Diagnosis of Metastatic Lymphadenopathy: An Institutional Study
Background: Lymphadenopathy is a common clinical complaint and has many causes/etiologies Both benign and malignant conditions can present with lymphadenopathy. FNAC in metastatic lymph nodes has acquired very wide accep...
FNAC Study of Tuberculosis among HIV Patients: Descriptive Study
Introduction: Clinical studies have shown the detrimental effects of tuberculosis on the course of HIV infection. The risk of death in HIVinfected patients with tuberculosis was reported to be twice that in HIVinfected...