Clinico-Hematological Study of Megaloblastic Anemia and Associated Megakaryocytic Alterations
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 2
Abstract
Context: Megaloblastic anemias are hematological disorders in which nuclear maturation lags behind the cytoplasmic maturation. Thrombocytopenia in megaloblastic anemia is because of ineffective thrombopoiesis in some studies and hypoproduction in some studies. Objective was to study the spectrum of clinicohematological features in megaloblastic anemia & comparative bone marrow aspiration study ofthrombocytopenia secondary to megaloblastic anemia due to hyper-destruction or hypoproduction. Aims: To understand the clinico-hematological spectrum of Megaloblastic anemia and associated megakaryocytic alterations. Methods and Material:100 cases of thrombocytopenia were included in the study. Bone marrow findings in 35 cases ofthrombocytopenia of megaloblastic etiology was compared with 40 cases of marrow proven hypo productive thrombocytopeniaand 25 cases of hyper destructive thrombocytopenia. Results: Most common age group presenting with megaloblastic anemia was 20-30 years,with M:F ratio 1.4:1. Most common complaints were fatigue and generalised weakness. 14.28% of patients had shown normal in number of megakaryocytes, 57.14% of patients had shown increased number 28.57% had shown decrease in number of megakaryocytes. Dysplastic megakaryocytes were seen in 43.75%, 26.25% & 30% of cases of megaloblastic anemia, acute leukaemia and immune thrombocytopenic purpura respectively. Conclusions: Both hypoproduction and ineffective thrombopoiesis are the underlyingmechanisms in megaloblastic thrombocytopenia as evidenced by marrow findings. We conclude that megaloblastic thrombocytopenia is to be included as separate category apart from hypo proliferative and hyper destructive groups. The presence of dysplastic megakaryocyte should not prompt interpretation of myelodysplastic syndromes and should always be correlated with patient’s clinico hematological parameter.
Authors and Affiliations
Manikantaswamy Marisetty
Keywords
Related Articles
- EP ID EP595772
- DOI 10.21088/ijprp.2278.148X.8219.9
- Views 74
- Downloads 0
Knowledge, Attitude and Perception amongst College Students Regarding Blood Donation
There is persistent shortage of active blood donors to meet the increased demand of blood in blood banks. The safety of blood with regard to the risk of transfusion transmissible infection is also an issue of utmost conc...
Fibroepithelial Polyps at Unusual Sites with Review of Literature
B27ackground: Fibroepithelial polyps are common small protuberant benign lesions primarily developing in areas where the skin forms creases such as neck, axillae, and groin. They may also arise on the face, usually on th...
Evaluation of Utility of Cytospin Technique in Fine Needle Aspirations
Fine needle aspiration cytology (FNAC) is an important diagnostic tool used preoperatively for diagnosis of palpable and non palpable mass lesions. Various techniques have been described for doing the procedure. Aims & O...
Does Hormonal IHC have Clinical Relavance in Pituitary Adenomas?
Background: Pituitary adenoma represent the third most common primary intracranial tumor in neurosurgical practice constituting about 10% of intracranial neoplasm. In accordance to the new WHO classification pituitary ad...
A Study on Prevalence of Unexpected Red Cell Antibodies in Multigravida Women Requiring Transfusion Support in a Tertiary Care Teaching Hospital in Chennai
Introduction:Blood group antigens can be immunogenic in individuals in whom the corresponding antigen is absent on the red blood cells. This mismatch can occur during transfusion or pregnancy. Aim of the Study: To estima...