Clinico-morphological Correlation and Diagnostic Accuracy of Synovial Biopsy in Synovitis: Experience in Tertiary Care Hospital
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 2
Abstract
Synovium is a specialized mesenchymal tissue in which varied pathological lesions can occur, but most common are non neoplastic lesions. Aim of the Study: To determine histopathological spectrum of non-neoplastic lesions of synovium and to correlate the clinical and histopathological diagnosis in our tertiary care hospital. Materials & Methods: Prospective study of 65 synovial biopsy samples. Patient’s complete clinical data, radiological findings, biochemical and serological parameters were obtained. Synovial fluid analysis was done in available cases. Histopathological examination of synovial biopsy tissue was done with routine and special histochemical stains wherever necessary. Statistical analysis for sensitivity, specificity and diagnostic accuracy was done. Results: We observed arthritis was common in 5th decade with Male-Female ratio of 1.7: 1. Most were monoarticular disease with the knee joint commonly affected. The common clinical manifestation was joint pain and swelling. The most common lesion was chronic nonspecific synovitis followed by osteoarthritis, tuberculous arthritis, rheumatoid arthritis and septic arthritis. One case of pigmented villonodular synovitis [PVNS], gouty arthritis and ochronotic arthritis were observed in our study. In our study, the diagnostic accuracy of synovial biopsy in comparison with clinical impression was 85% with 73% sensitivity, 97% specificity, 96% positive predictive value and 78% negative predictive value, 27%false negative rate and 3% false positive rate. Conclusion: In our study, we observed that synovial biopsy is cost effective and offers immense help to clinicians in providing appropriate treatment for patients, especially in long standing and subtle inflammatory lesions.
Authors and Affiliations
Bhuvanamha Devi Ramamurthy
Keywords
Related Articles
- EP ID EP462783
- DOI 10.21088/ijprp.2278.148X.6217.1
- Views 114
- Downloads 0
Fine Needle Aspiration Cytology of Palpable Breast Lumps with Histologic Correlation: A Two-Year Review
Aims: To determine the histopathologic correlation of breast FNAC. Settings and Design: This is a two-year prospective study of breast lumps seen at Department of Pathology, Dr. S.N. Medical College, Jodhpur (Rajasthan)...
Histopathological Study of Tumours of Epidermis and Epidermal Appendages
Introduction: Skin is a complicated protective covering [1]. It is divided into two seemingly separate but functionally interdependent layers, i.e., epidermis and dermis. Adnexae extend from epidermis into the dermis and...
Histopathological Patterns of Gall Bladder Diseases in Routine Cholecystectomy Specimens: A Hospital-Based Study from a Rural Medical College, Uttar Pradesh
Introduction:Cholelithiasis is the most common disease affecting gallbladder. Gallstones cause several histological changes in gallbladder mucosa like acute and chronic inflammation, metaplasia, hyperplasia, calcificatio...
Blood Donor Deferral Pattern Analysis in a Tertiary Care Center: A Study of 4902 Subjects
Introduction: Blood safety is always remaining a point of concern. In blood bank all the procedures are starting with donor selection. Individuals disqualified from donating blood are known as “deferred” donors Aim: The...
Utility of Fine Needle Aspiration Cytology in Nonneoplastic Lesions of Lymphnodes
Introduction: The goal of fine needle aspiration cytology of lymph node is essentially to distinguish benign from malignant lesions. Nonneoplastic disorders that can manifest in lymph nodes include those with specific di...