Clinico Pathological Analysis of Uterine Serous Carcinoma in a Cancer Centre from Northern Kerala-A Retrospective Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 5
Abstract
ABSTRACT Introduction: Uterine Serous Carcinoma (USC) accounts for 10% of malignancies of uterine corpus. They are characterised by high propensity for local spread, extra uterine metastasis, recurrence and are having poor prognosis. The disease can be highly aggressive even if it is confined to uterus at time of surgery. Aim: To assess the clinico-pathologic features of uterine serous carcinoma in patients of north Kerala and to analyse its predictors of outcome. Materials and Methods: Data of cases diagnosed with uterine serous carcinoma for five years from 2012 January to 2016 December were retrieved from medical library. Overall survival and progression free survival were assessed. Results: It is observed that all patients were post menopausal women with the age of 59.5+8.535 with predominant clinical presentation of vaginal bleeding. As per the FIGO staging, 13 patients were in Stage I, 11 cases were in Stage III, 4 cases were in IV and no cases reported in Stage II. Out of 28, 9 cases (32.1%) were died and 12 patients (42.8%) had recurrence during the follow-up period. 19 cases (67.9 %) had the five year over all survival. For stage I patients the overall survival was 76.9%, Stage III had 72.7%, and Stage IV had only 25%. 3 out of the 13 cases in Stage I, 6 out of 11 cases in Stage III and 3 out of 4 cases in Stage IV showed recurrence irrespective of the adjuvant treatment. Conclusion: Uterine serous carcinoma has distinct clinico-pathologic features compared to the more common endometrioid carcinoma. It carries poor prognosis. Complete surgical staging with close follow-up is needed even in cases confined to uterus.
Authors and Affiliations
Indusarath . , Aswathi Krishnan, Sangeetha K Nayanar, Sampada Dessai, Maya Padmanabhan
Keywords
Related Articles
- EP ID EP522514
- DOI 10.7860/JCDR/2018/34658.11539
- Views 36
- Downloads 0
A Rare Presentation of an Incomplete Vertical Fracture in the Furcation Area of a Mandibular Molar and its Multidisciplinary Management
Specialists in the dental field often get habituated to having a partial or biased assessment of clinical findings or disorders by virtue of practicing a niche speciality over long periods of time. This can lead to a dis...
Effect of Magnesium Sulphate and Dexmedetomidine on Blood Loss during Lumbar Spinal Fusion Surgeries
ABSTRACT Introduction: Spine surgeries pose unique challenges to the anaesthesiologist in maintaining stable haemodynamics, relatively dry operative field and concerns over patient positioning during surgery. Aim: The pr...
Tooth Extraction in a Hepatic Cirrhosis Patient Receiving the Novel Oral Thrombopoietin Receptor Agonist Lusutrombopag
Lusutrombopag was administered to a patient with thrombocytopenia due to chronic liver disease before an invasive procedure. Lusutrombopag, the first drug of its kind, was developed to improve platelet count thereby, avo...
Anaplastic Pleomorphic Xanthoastrocytoma in a Case of Neurofibromatosis Type 1: A Case Report
Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour comprising only <1% of primary brain tumours which is seen in children and young adults. Only 9-20% of the PXA shows anaplastic features and this has a bad progn...
Evaluation of Percutaneous Vertebroplasty for Management of Symptomatic Osteoporotic Compression Fracture
Introduction: Osteoporotic vertebral compression fractures are a leading cause of disability and associated morbidities among Indian population. Worldwide, approximately 20% of elderly population above 70 years and 16% o...