Clinico-pathological study of endometrium in Dysfunctional Uterine Bleeding (DUB): An experience with D&C specimens
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 6
Abstract
Abstract: Dysfunctional Uterine Bleeding (DUB) is one of the most common gynaecological conditions presenting with a variety of patterns of bleeding per vagina. It is designated to be the most common cause of hysterectomy by many studies. This study was undertaken to study the changes in endometrium in patients diagnosed as DUB and to correlate their socio-demographic and clinical data with the histopathological findings.The study included 150 patients selected by Random sampling technique who were diagnosed to have Dysfunctional uterine bleeding between the period of August 2013 to April 2015 by the Department of Pathology, SIMS & RH, and Tumkur. The patients were initially subjected to routine physical examination and haematological investigations followed by Dilatation and Curettage (D&C). The D&C samples were received by the Dept. of Pathology, SIMS & RH, stained using H&E, examined and interpreted. The histopathological findings in the received endometrial samples were correlated with parameters such as age, parity, haemoglobin concentration and clinical presentation. Special stains such as PAS, Reticulin and Vangiesson’s stain were done when ever indicated. Statistical analysis was done using MS excel.The patients belonged to various age group with a maximum incidence between 36-40 years (24.7%) and 41-45 years (25.3%). DUB was commonly seen in multiparous women. Menorrhagia was the most common pattern of bleeding (53.3%) and was most commonly encountered in the age group of 31-40 years. 65.3% of patients were moderately anaemic while 0.7% had severe anemia. Most of the D&C specimens showed hyper plastic endometrium (42%) followed by normal endometrium in 40% specimens. An increased incidence of menorrhagia was noted in patients who have undergone tubal ligation (n=90, 60%). Organic lesions were found in 6 patients.Clinical findings, clinical diagnosis and histopathological findings correlated well in 96% of the patients. Considering all the observations, DUB is caused due to the proliferative hormonal influence on the endometrium in the perimenopausal women. Keywords:Dysfunctional uterine bleeding, dilatation and curretage, histopathology, endometrium, cystoglandular hyperplasia.
Authors and Affiliations
Dr. Sharada M S, Mr. Ebinesh A
Keywords
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