Clinicohistopathological study of cutaneous vasculitis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Background: Vasculitides comprise a group of disorders characterized by inflammation directed at blood vessels, identified by histologic examination. Biopsy is the gold standard for the diagnosis of cutaneous vasculitis. Aims:1) to study in detail, the classic histopathological features of cutaneous vasculitis and correlate them with the clinical features for the emergence of a composite diagnosis of cutaneous vasculitis.2) to evaluate the role of Direct Immunofluorescence in the diagnosis of cutaneous vasculitis. Materials and Method: this cross sectional descriptive study was conducted in the Department of Pathology, Government Medical College, Thiruvananthapuram, during a period of 2 years in 90 cases having a clinical diagnosis of cutaneous vasculitis. Histopathological findings of the skin biopsy specimens were noted. Direct Immunofluorescence was done in a selected number of cases. Data was analyzed using SPSS software. For all statistical evaluations, a 2-tailed probability of value, <0.05 was considered significant. Results: This study shows good correlation between clinical and histopathological diagnosis (93.3% of cases) and is statistically significant. DIF acts as an adjuvant investigation in cases suspected to be immunologically mediated.
Authors and Affiliations
Twinkle S Prasad
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