Clinicohistopathological study of cutaneous vasculitis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Background: Vasculitides comprise a group of disorders characterized by inflammation directed at blood vessels, identified by histologic examination. Biopsy is the gold standard for the diagnosis of cutaneous vasculitis. Aims:1) to study in detail, the classic histopathological features of cutaneous vasculitis and correlate them with the clinical features for the emergence of a composite diagnosis of cutaneous vasculitis.2) to evaluate the role of Direct Immunofluorescence in the diagnosis of cutaneous vasculitis. Materials and Method: this cross sectional descriptive study was conducted in the Department of Pathology, Government Medical College, Thiruvananthapuram, during a period of 2 years in 90 cases having a clinical diagnosis of cutaneous vasculitis. Histopathological findings of the skin biopsy specimens were noted. Direct Immunofluorescence was done in a selected number of cases. Data was analyzed using SPSS software. For all statistical evaluations, a 2-tailed probability of value, <0.05 was considered significant. Results: This study shows good correlation between clinical and histopathological diagnosis (93.3% of cases) and is statistically significant. DIF acts as an adjuvant investigation in cases suspected to be immunologically mediated.
Authors and Affiliations
Twinkle S Prasad
Keywords
Related Articles
- EP ID EP504534
- DOI -
- Views 42
- Downloads 0
Congenitally Fused Kidney Mal-Positioned In the Sacral Region
Normally the anatomical position of kidneys is at the level of T12-L3 vertebrae in relation to spine. It is supplied by renal artery which is a branch of abdominal aorta.
Study of Morphological Features of Carcinoma of Breast in Relation to ER/PR and Her2/neu Status
Introduction: Breast cancer in India is the most common cancer among women in the urban areas and ranks second in the rural population. In this study our aim is to correlate the morphological features of breast carcinoma...
Granulomatosis with Angitis of Lung treated with Steroids and Rituximab– Case Report and Review of Literature
Granulomatosis with angitis, formerly termed Wegener’s granulomatosis (WG) is an uncommon autoimmune disease with multi‑system involvement, the pathological hallmark of which is necrotizing granulomas with vasculitis. Al...
Role of Exchange Transfusion In Dapsone Poisoning
Suicidal ingestion of Dapsone can lead to severe methemoglobinemia. Exchange Transfusion decreases Meth-Hb level. We present a young female with suicidal ingestion of Dapsone who responded to Exchange Transfusion
Prevalence of Refractive Error among College Students in South India: A Pilot Study
Introduction: Uncorrected refractive error contributes to the leading cause of moderate to severe visual impairment. Correction of refractive error in school children will make a dramatic improvement in educational poten...