Clinicopathologic study of Acute Viral Encephalitis Syndrome in Greater Gwalior region-A one year study
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Background-Viral Encephalitis has existed in world from time immemorial and has concurrently inflicted hazardous and lethal diseases to human beings. The most challenging aspect of viral encephalitis infection is its definite diagnosis. Objectives-The present study was carried out in tertiary centre to find out the incidence, the various diagnostic modalities-conventional CSF and hematological analysis as well as the newer molecular techniques PCR and RTPCR and Clinicopathologic correlation of Acute Viral Encephalitis Syndrome. Material & Method-The study was a one year prospective study carried out in JA Group of Hospitals in greater Gwalior region. It included collection of blood and CSF samples of 120cases and 120 controls and determining the etiological agents of dreadful illness by conventional and newer molecular techniques RTPCR and Taqman Real Time PCR. Results-The incidence of Acute Viral Encephalitis in our study was found to be 5.8%. Males were more commonly affected and the incidence was found to be more in children less then 10 years of age. Enterovirus(EV) and Measles was identified as the most common etiological agents in Greater Gwalior region. Out of 7 positive cases 5 were detected in CSF and 2 were in serum indicating specificity of CSF more than serum. CSF Pleocytosis was seen in 61 cases out of 120. Conclusion – Newer molecular techniques used for specific diagnosis can prove a big asset to society as they facilitate the early diagnosis of Acute viral encephalitis and reduce the morbidity and mortality. Diagnosis of Acute Viral Encephalitis has improved remarkably with application of Rapid molecular techniques eg RTPCR ( Reverse Transcription)and Real time RTPCR for early detection & identification of virus in clinically suspected samples.
Authors and Affiliations
Dr Reena Jain MD
Keywords
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