CLINICOPATHOLOGICAL ANALYSIS AND CLASSIFICATION OF NEUROBLASTIC TUMOURS - EXPERIENCE OF PAEDIATRIC HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 26
Abstract
[b] BACKGROUND[/b]: Neuroblastomas are the most common extracranial solid tumors in infancy and childhood. They are biologically distinctive and interesting paediatric tumors. Neuroblastoma is an embryonal malignancy of sympathetic nervous system arising from neuroblasts. [b]AIMS AND[/b] [b]OBJECTIVES[/b]: The objective of the present study is to study the spectrum, morphological features of neuroblastic tumors and to classify the tumors applying the International Neuroblastoma Pathology Classification (INPC). [b]MATERIAL AND METHODS[/b]: This is a 4.5 year retrospective study undertaken at Department of pathology, Paediatric Referral Hospital, Hyderabad. A total of 41 cases of neuroblastic tumors were included in our study from January 2004 to June 2009. The Haematoxylin and eosin stained slides were evaluated for histopathological features including differentiation, presence or absence of Schwannian stroma and Mitotic-Karyorrhectic index (MKI). They were clinically staged using International Neuroblastoma staging System (INSS) and graded according to International Neuroblastoma Pathology Classification (INPC). [b]OBSERVATIONS AND RESULTS[/b]: The commonest age group was found to be less than 1.5 years and more common in boys. The most common presenting site was adrenal gland (36.5%) followed by retroperitoneum (31.7%).Most of the patients presented in advanced clinical stage (Stage 4) with mass abdomen as the presenting symptom (41.4%). Of the 41 cases, 14 were observed as favourable histology (FH) subgroup while 27 as unfavourable histology (UH) subgroup.[b]CONCLUSION[/b]: INPC has formulated the classification of neuroblastic tumors based on grade of neuroblastic differentiation and MKI value linked with age at presentation. Histopathologic prognostication permits early identification of the patient at risk of relapse or fatal outcome
Authors and Affiliations
Ramani M, Kazi Wajid, Radhika Krishna, Ramesh Reddy, Sreenivasa Reddy, Ramya Theja, Puja Deshmukh, Sujeeva Swapna
Keywords
Related Articles
- EP ID EP106468
- DOI 10.14260/jemds/906
- Views 90
- Downloads 0
A CLINICAL STUDY OF MORBIDITY AND MORTALITY PATTERN OF LATE PRETERM INFANTS AT SNCU, WARANGAL
OBJECTIVE A clinical study of morbidity and mortality pattern of late preterm infants in comparison with term infants. STUDY DESIGN Prospective observational study. SETTING SNCU, Mahatma Gandhi Memorial Hos...
PRIMING PRINCIPLE AND RAPID SEQUENCE INTUBATION WITH NON-DEPOLARISING MUSCLE RELAXANT VECURONIUM BROMIDE
BACKGROUND Succinylcholine cannot be used for rapid sequence intubation (RSI) in several situations due to associated side effects. Vecuronium bromide has faster onset of time among non-depolarising muscle relaxants and...
EVALUATION OF THE EFFICACY OF THE THREE REGIMENS OF VAGINAL MISOPROSTOL IN THE TERMINATION OF FIRST TRIMESTER PREGNANCY- A RANDOMISED CONTROLLED STUDY
BACKGROUND An abortion is the removal or expulsion of an embryo or foetus from the uterus, resulting in or caused by its death. Abortion in the first trimester is safe compared to the second trimester and medical methods...
DIMENSIONAL ACCURACY OF PUTTY-WASH ONE-STEP AND TWO-STEP IMPRESSION TECHNIQUE IN FABRICATION OF FIXED PARTIAL DENTURE
BACKGROUND Impression is crucial step in fabrication of fixed partial denture (FPD). The most common impression technique used in fabrication of fixed partial denture (FPD) is putty-wash impression technique, divided int...
A SYNDROME OF EXTENSIVE PERIPAPILLARY MYELINATED NERVE FIBRES, HIGH IPSILATERAL MYOPIA AND REFRACTORY AMBYLOPIA
Myelinated retinal nerve fibers are rare developmental anomalies present in 0.5- 1% of all eyes. Occur due to myelination of ganglion cells beyond the lamina cribrosa during embryonic development. Reports of am...