Clinicopathological and immunohistological profile of infiltrating ductal carcinoma breast in a tertiary care centre of western UP- A study of 100 cases
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 4
Abstract
Introduction Breast cancer is the most common cause of death of women worldwide and it is the most common malignancy in Indian females followed by carcinoma cervix Diagnosis involves various modalities like clinical examination radiological investigations fine needle aspiration cytology FNAC and histopathological examination Recently immunohistochemistry IHC is becoming a standard methodology in pathology laboratories worldwide IHC provides substantial information with regard to diagnosis therapeutic prediction and prognosis of breast cancer Therefore hormonal studies evaluating the status of estrogen receptor ER progesterone receptor PR and Human epidermal growth factor2 Her2 neu have become a part and parcel of the histopathology reportingMaterials and Methods Present study included 100 cases of Infiltrating Ductal Carcinoma IDC breast diagnosed in mastectomy specimens received in department to Pathology Rohilkhand Medical College and Hospital Bareilly between July 2014 to June 2017 Other histological variants were excluded from the study Various parameters including age site tumor size lymph node metastasis histopathological grading hormone receptor status namely ER PR and Her2 neu were studied The histological grade was correlated with the hormone receptor statusResults Majority patients belonged to the age group of 4150 years 34 Most of the carcinomas were of Bloom Richardson grade II 73 In terms of the IHC profile majority were ERPR negative and Her2 neu positive 45Conclusion Breast carcinoma should be studied in all respects in order to understand its behaviour Additionally immunohistopathological studies should be carried out in all cases in order to obtain predictive and prognostic informationKeywords Breast Carcinoma Grade Hormone receptor Bloom Richardson
Authors and Affiliations
Shweta Agarwal, Mithila Bisht, Ranjan Agrawal
Keywords
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- EP ID EP475934
- DOI 10.18231/2394-6792.2018.0118
- Views 40
- Downloads 0
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