Clinicopathological Aspects, Morphological Features And Immunohistochemical Profile of Breast Carcinoma – A Study of 95 Cases.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Breast cancer is the most common cancer and leading cause of death among women in our country. Clinical management of breast cancer relies on the clinical and pathological predictive and prognostic variables mainly tumor size, histological grade, staging, lymph node status, lymphovascular invasion and hormonal receptor status. The purpose of this study is to assess the clinical data, evaluate the morphological parameters in the breast cancer patients and their correlation with immunohistochemical analysis. 95 cases of breast carcinoma from January 2015 to December 2016 reported in the Department of Pathology, Government Royapettah Hospital, Kilpauk Medical College, Chennai were included in the study. Relevant clinical data, mode of presentation, tumor laterality, gross and microscopic features were noted. Haematoxylin and Eosin stained tissue sections slides were examined.In the present study, most commonly affected female population were in the age group 41 -59 years( 69%). Majority of tumors were diagnosed as infiltrating ductal carcinoma NOS type (77%), followed by invasive lobular carcinoma (10%), mucinous carcinoma (1%) and others.Most of the tumors were histopathological grade II followed by grade III. Lymphovascular invasion was found to be 3.1%. ER (52 %), PR (22.6%), and HER2/neu ( 21.5%). Histopathological grade was found to be inversely proportional with receptor positivity, which showed that as the grade increases, receptor positivity will decrease both of which indicates poor prognosis. The present study shows a significant correlation between various pathological aspects, histopathological grade and immunohistochemical status of breast carcinoma which will be helpful to some extent in determining the prognosis, treatment modalities and response to therapy in practice.
Authors and Affiliations
Dr. M. Narmatha, Dr N. Andal
Keywords
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- EP ID EP256723
- DOI 10.9790/0853-1609094550
- Views 56
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