Clinicopathological Characteristics and Immunophenotype of 67 Patients with Multiple Myeloma.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
Objective: Multiple myeloma (MM) is a neoplastic disorder characterized by proliferation of a single clone of plasma cells derived from B cells. Our aim is to study demographic and clinicopathological features of adult Turkish MM patients at presentation. Materials and Methods: This single center retrospective study extended from January 2010 to December 2017. Patient data were obtained from hospital database. Results: Twenty-nine (43.3%) female, and 38 (56.7%) male patients with an overall mean age of 65.4 ± 10 years (range, 35 - 87 years) were included in the study. The most common complaints in patients were bone , body pain, and fatigue. In 64.2% of the patients had symptoms related to acute kidney injury. Thirty-nine (58.2%) patients had lytic lesions in one and more than one bones. Bone lesions were frequently localized in the vertebra (n = 23, 59%). Immunohistochemical evaluation of bone marrow biopsy specimens revealed kappa light chain globulin, and IgG heavy chain globulin positivities in 50.7% and 72.4%, of the patients, respectively. The mortality rate was 65.7% in all cases. Conclusion: Demographic, and clinopathological characteristics of the patients with MM complied with those of the literature. Median survival time of the patients was 7.6 months.
Authors and Affiliations
Dudu Solakoglu Kahraman
Keywords
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