Clinicopathological Evaluation of Various Prognostic Factors in Breast Cancer Along with Hormonal Receptor Status and HER2/neu Expression
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 1
Abstract
Introduction: The prevalence of hormone receptor positive breast cancer in Asian countries is found to be lower than the western world where more than 50% of the tumors express hormone receptors. Studies have found consecutive decrease of ER, PR expression as a measure of differentiation of the tumour with low grade having the highest and high grade having the lowest ER/PR expression. Detection of vascular invasion in the primary tumor is a marker of metastatic potential and has prognostic significance, particularly in the lymph node negative group and helps to predict both recurrence and long-term survival. Aims and Objectives: To study the expression of ER, PR and HER2/neu status by immunohistochemistry and correlation of clinicopathological parameters with hormone receptor status and HER2/neu expression. Results: In the present study the age range of the patients was between 35-80 years. Out of 53 cases, majority (72%) of them were invasive ductal carcinoma. Other tumors included medullary carcinoma, lobular carcinoma, metastatic carcinoma and poorly differentiated carcinoma. Nineteen out of 53 tumors (36% of the cases) showed triple negativity and only one tumor showed triple positivity. Of the total cases 32% of the tumors were ER+/PR+, 17 % ER+/PR- and 4% showed ER-/PR+. Conclusion: This study highlights the importance of various prognostic factors and hormone receptor status evaluation that will aid in therapeutic intervention.
Authors and Affiliations
Shashidhar M. R
Keywords
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- EP ID EP512442
- DOI 10.21088/ijprp.2278.148X.7118.13
- Views 51
- Downloads 0
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