Clinicopathological features of thyroid Hürthle cell neoplasm in 73 cases
Journal Title: Chinese Journal of Clinical Research - Year 2025, Vol 38, Issue 1
Abstract
<b>Objective</b> To explore the clinicopathological features of benign and malignant thyroid Hürthle cell neoplasm (HCN). <b>Methods</b> A retrospective analysis was performed on 73 patients diagnosed with HCN and underwent thyroid surgery in the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2016 to June 2023. The patients were divided into Hürthle cell adenoma (HCA) group ( n =63) and Hürthle cell adenocarcinoma (HCC) group ( n =10) according to the postoperative pathological results. The clinicopathological features of the two groups were analyzed and compared. Logistic regression was used to analyze the influencing factors of malignant HCN, and their diagnostic efficacy for HCC was analyzed by receiver operating characteristic (ROC) curve. <b>Results</b> There was no significant difference between the two groups in general data, comorbidities, pathological features, thyroid function and immunohistochemical features ( P ＞0.05). The tumor diameter in HCC group was smaller than that in HCA group ［0.75 (0.38,1.00) cmvs 2.20 (1.25,3.15) cm,Z =2.595,P =0.009］, and the proportion of bilateral resection was higher than that in HCA group (30.00%vs 6.35%,P =0.049). Logistic regression analysis showed that the tumor diameter ( OR =0.311,P =0.022) and whether acepted bilateral resection ( OR =0.118,P =0.040) were independently related to HCC. ROC curve analysis revealed that the area under the curve (AUC) of mass diameter in the diagnosis of HCC was 0.756, the optimal cut-off value was 1.1 cm, with a sensitivity of 0.794, and a specificity of 0.800. <b>Conclusion</b> The size of the mass is of great significance for the judgment of HCA and HCC.
Authors and Affiliations
WANG Cuizhong, ZHONG Yichen, SHEN Tong, RUI Qiang, WANG Chenxi, JIANG Zhiwei, GONG Guanwen
Keywords
Related Articles
- EP ID EP759902
- DOI -
- Views 18
- Downloads 0
The relationship between serum IL-6, hs-CRP, SAA and acute lung injury in elderly patients with sepsis and their prognostic value
Objective To analyze the prognostic predictive value of combined serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and amyloid A (SAA) tests in elderly patients with sepsis combined with acute lu...
Analysis of intraoperative temperature changes and postoperative related indexes in patients undergoing thoracoscopic surgery and thoracotomy
Objective：To observe and analyze the characteristics of temperature changes at different time points and the changes of postoperative indexes in adult thoracotomy and thoracoscopic surgery. Methods：A retrospective anal...
Effects of nerve block in different areas on opiate dosage and stress response in patients undergoing thoracoscopic radical resection of lung cancer
<b>Objective</b> To explore the effects of ultrasound-guided serratus anterior plane block (SAPB) and thoracic paravertebral block (TPVB) on opiate dosage and stress response in patients undergoing thoracoscopic radical...
Efficacy and prognosis of transurethral holmium laser en-blocresection of bladder tumor in the treatment of non-invasive bladder cancer
Objective To investigate the efficacy and prognosis of transurethral holmium laser en-bloc resection of bladder tumor (HOLRBT) and transurethral resection of bladder tumor (TURBT) in the treatment of non-invasive bladder...
Preliminary application of Acostream percutaneous aspiration thromboembolectomy sequential low-dose alteplase in the treatment of lower extremity deep vein thrombosis
Objectiv To investigate the efficacy and safety of Acostream percutaneous aspiration thromboembolectomy (PAT) sequential low-dose alteplase (rt-PA) in the treatment of lower extremity deep vein thrombosis(LEDVT). Method...