Clinicopathological profile of neuroendocrine tumors of gastrointestinal tract
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Neuroendocrine neoplasms are derived predominately from enterochromaffin or Kulchitsky39s cells The estimated prevalence of neuroendocrine tumors NET is 1 to 2 cases per 100000 people of which gastrointestinal tract GIT is the most common site And being a rare tumor it is less studiedAim of the Study To study the clinicopathological profile of Neuroendocrine tumors of GITMaterials and Methods All specimens of neuroendocrine tumors received from the Department of Surgery and Department of digestive health diseases during the period from September 2008 to September 2012 were included Clinical details were collected from the medical records in all cases The tumors were classified based on WHO classification 2010 using morphological findings on HE slides Immunohistochemistry was done in 40 cases using Synaptophysin Chromogranin and Neuron specific enolaseResults There were 886 neoplasms diagnosed in GIT of which 53 598 were NET The mean age of presentation was 50 years The male Female ratio observed is 21 The most common presenting symptoms were abdominal pain followed by loss of appetite and weight Carcinoid syndrome was seen in 253 38 patients The most common site involved was Stomach followed by duodenum and ileum NET Grade 1 was seen in 22 cases NET Grade 2 was seen in 9cases NET Grade3 was seen 4 cases and mixed adenocarcinoma and neuroendocrine carcinoma MANEC was seen in 18 cases Metastasis to liver was seen in 3 cases Most of the NET tumors expressed the IHC markers 95 were positive for NSE 875 were positive for Synaptophysin and 825 cases were positive for ChromograninConclusion Neuroendocrine tumors NETs are uncommon malignancies of GIT Stomach was the most common anatomical site NET grade 1 was the most common histological subtype IHC markers NSE Synaptophysin and chromogranin can be used in diagnosis of NETsKeywords Neuroendocrine tumors Gastrointestinal tract Histomorphology Immunohistochemistry Grading
Authors and Affiliations
Kalaivani Selvi S. , Jeya Shambavi J. , Narmadhar R. , Rajalakshmi V.
Keywords
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- EP ID EP482790
- DOI 10.18231/2581-3706.2018.0058
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