Clinicopathological study of cutaneous vasculitis
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 12
Abstract
Introduction: Cutaneous vasculitis hasvaried clinical manifestations. It may be idiopathic or associated with a spectrum of underlying conditions. Skin is involved in both small vessel vasculitisand medium vessel vasculitis. Majority ofvasculitic cases are relatively benignand self limiting in nature associatedwith wide spectrum of clinical associations. The histopathological features may help in the confirmation of clinical diagnosis. Materials and Methods: The study was conducted atdepartment of dermatology for a period of two years. Patients clinically diagnosed as cutaneous vasculitis were included in the study. 38 patientswith features suggestive ofcutaneous vasculitis were included. Detailed history and clinical examination were done andtwo skin biopsies were taken from each patient for routine histopathology and direct immunofluorescence Results: A Total of 38 patients studied, clinically 27(71.05%)were Leucocytoclastic vasculitis (LCV) and 10(26.1%) cases were Henoch Schonlein purpura (HSP) and one (2.63%) was Urticarial vasculitis. Based on histopathological examination majority 92.1% were diagnosed as leukocytoclastic vasculitis. DIF showed immune reactants in 76.47%of which IgA deposits were commonest in 69.23% followed by C3 in 61.53% and IgG, IgM in 7.69% each. Systemic involvement was seen in 52.63% patients. About 57.89% cases were found to be idiopathic Drugs were implicated in21.05% cases, infections in18.42% and connective tissue disorders in 2.63%. Conclusions: Skin biopsy and DIF were in concordance with clinical diagnosis in majority of the cases
Authors and Affiliations
Sudharani Chintagunta, Katukuri Pavani, Geeta Kiran Arakkal
Keywords
Related Articles
- EP ID EP420053
- DOI 10.7439/ijbr.v6i12.2699
- Views 100
- Downloads 0
Unusual Peritoneal Encapsulation: Case Report
Peritoneal encapsulation is an exceedingly rare developmental abnormality in which the small bowel is completely encased in an accessory peritoneal sac. Diagnosis is intraoperative as the clinical signs rarely help in di...
Is Apolipoprotein B and Small, Dense low density lipoprotein a better marker of cardiovascular risk?
The association between low density lipoprotein cholesterol and cardiovascular risk is well established. However, the measurement of the cholesterol content of this lipoprotein incompletely accounts for the risk of cardi...
Prevalence of the absence of Palmaris longus muscle in the students of Kathmandu University
Background: Palmaris longus muscle is one of the superficial muscles of flexor compartment of forearm. Its main function is to anchor the skin and fascia of the hand. It is a weak flexor of the hand at wrist and tenses t...
Neutral Zone- A Clinical Report
Edentulism from a long term results in high resorption of lower edentulous ridge which often pose a problem in stability of mandibular complete dentures. It is a challenge for a prosthodontist to rehabilitate those patie...
Relooking at Nitrofurantoin as drug of choice for empiric treatment of community acquired uncomplicated urinary tract infections: An effective and economic treatment option
Introduction: Urinary tract infections (UTI) caused by multidrug resistant bacteria necessitate the use of broad spectrum expensive antibiotics, which enhance antibiotic pressure. It would be ideal to look at older less...