Clinicopathological Study of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Introduction: NAFLD is a group of conditions that have in common the presence of hepatic steatosis (fatty liver), in individuals who do not consume alcohol. It has become the most common cause of chronic liver disease in the United States and in its various forms probably affects more than 30% of the population. Hepatic steatosis may range from a 'benign' indolent deposition of fat to severe lipotoxicity-induced steatohepatitis with necroinflammation known as Nonalcoholic steatohepatitis(NASH).NASH is an overlooked complication of Type 2 diabetes mellitus (T2DM) that if missed may carry serious long-term consequences. Objectives of the study: 1)To study the prevalence of Nonalcoholic fatty liver disease and Nonalcoholic steatohepatitis in patients with Type 2 Diabetes Mellitus and 2) To study the features of NASH by liver biopsy. Settings & Design: Prospective observational study was conducted on a total of 90 patients, aged above 40yrs with type 2 diabetes mellitus. Materials & Methods: Fatty liver by Ultrasonography & various other relevant factors were measured in all study subjects. Based on USG , patients were divided into two groups 1)NAFLD group-altered echo texture of the liver parenchyma and 2)normal liver group . liver biopsy was done in willing NASH patients diagnosed by ultrasound and biopsy slides were examined histopathologically. Results: Incidence of Non-alcoholic fatty liver disease in our study is around 62 (59.7%) of which 37 (55%) are males and 25 (45%) are females. 20 patients diagnosed as NASH by ultrasound underwent liver biopsy Conclusion: The prevalence of NAFLD is high amongst Type2DM patients and considering this risk , NAFLD should be actively sought out and treated in patients with diabetes
Authors and Affiliations
B Subhashini, E Lakshman, D Praveen Kumar
Keywords
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