Clinicopathological Study of Renal Function in Type 2 Diabetics in Ile-Ife, Southwest Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 16, Issue 9
Abstract
Aims: To determine the prevalence and clinico-pathological correlates of diabetic nephropathy among type 2 diabetics in Southwest Nigeria. Study Design: Descriptive, cross-sectional. Place and Duration of Study: Renal Unit, Medicine Department, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Southwest Nigeria. Methodology: Percutaneous ultrasound-guided renal biopsy was carried out in 40 consenting type 2 diabetic adults out of 88 patients in stages 3 and 4 chronic kidney disease using the Kidney Disease Improving Global Outcomes classification. Results: Eighty eight (48.1%) of the one hundred and eighty three subjects with mean age of 58.05(±6.10) years had clinical Diabetic Nephropathy. The duration of diabetes was 9.55(±4.1) years. Median protein excretion was 0.55 g/day. Mean estimated Glomerular Filtration Rate was 45.1(±12) ml/min. Thirty nine renal (97.5%) tissues showed glomerular basement membrane thickening. There was a positive correlation between the systolic blood pressure and severity of glomerular lesions (r=0.480, p=0.002), interstitial changes (p=0.602, r<0.001) and vascular lesions (0.429, 0.006). The diastolic blood pressure correlated with glomerular lesions (r=0.500, p=0.001), interstitial changes (0.479, 0.002), vascular lesions (p=0.431, r=0.006), nodular glomerulosclerosis (r=0.333, p=0.036) and diffuse glomerulosclerosis (r=0.372, p=0.018). Urinary protein excretion correlated with severity of glomerular lesions (r=0.457, p=0.003), vascular changes (r=0.483, p=0.002) and diffuse glomerulosclerosis (r=0.407, p=0.009). Diabetic retinopathy correlated positively with severity of glomerular lesion (r=0.406, p=0.009) and diffuse glomerulosclerosis (r=0.547, p<0.001). Conclusion: The prevalence of diabetic nephropathy among type 2 diabetics in Ile-Ife is high. Glomerular basement membrane thickening was the most prevalent renal pathology. There was a positive correlation between blood pressure, protein excretion, retinopathy and renal histology.
Authors and Affiliations
Akinbodewa Ayodeji Akinwumi, Okunola Oluyomi, Adelusola A. Kayode, Sanusi Abubakr Abefe, Arogundade Fatiu Abiola, Ikem T. Rosemary, Akinsola Adewale
Keywords
Related Articles
- EP ID EP341172
- DOI 10.9734/BJMMR/2016/27021
- Views 57
- Downloads 0
Autoimmune Liver Diseases in Native Black Africans: Extremely Rare or Inadequately Investigated Diseases?
Background: Autoimmune liver diseases (autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis) are conventionally considered to be very rare among native black Africans where chronic hepatitis...
High magnitude of diabetes mellitus among Active Pulmonary Tuberculosis Patients in Ethiopia
Aim: The main aim of this study was to determine the prevalence of diabetes mellitus in patients with active pulmonary tuberculosis at the University of Gondar Teaching Referral Hospital, northwest Ethiopia. Study Design...
Common High Altitudes Illnesses a Primer for Healthcare Provider
Exposure to high altitude imposes significant strain on cardiopulmonary system and the brain. As a consequence, sojourners to high altitude frequently experience sleep disturbances, often reporting restless and sleepless...
Effect of Isolation Stress on Glucose/Lipid Metabolism in Spontaneously Diabetic Torii (SDT) Fatty Rats
Aim: The Spontaneously Diabetic Torii (SDT) fatty rat is a novel obese type 2 diabetic model, showing hyperphagia, obesity, and diabetes mellitus from a young age. In this study, we investigated the effects of isolation...
Search for Escherichia coli O157:H7 and Other Enterohaemorrhagic Escherichia coli in Diarrhoeal Cases in Abuja, Nigeria
Aims: To detect the sporadic involvement of shiga toxin producing Escherichia coli (STEC) O157:H7 or any other enterohaemorrhagic E. coli in gastro-intestinal (diarrhoeal) infections. Study Design: The study is a cross s...