Clopidogrel Resistance in Stroke Cases
Journal Title: Istanbul Medical Journal - Year 2019, Vol 20, Issue 6
Abstract
Introduction: Clopidogrel treatment is one of the standard treatments in terms of reducing mortality and morbidity in patients with cerebrovascular disease diagnosed with large artery atherosclerosis. However, resistance to clopidogrel treatment is a significant problem today. In this study, we aimed to retrospectively investigate clopidogrel resistance (CR) and related factors in patients with detected large artery atherosclerosis who were evaluated for cerebrovascular disease. Methods: A total of 96 patients, including 31 females and 65 males, were evaluated in the neurology and neuroradiology clinics with the diagnosis of cerebrovascular disease. Age, gender, presence of CR, and complete blood count values [platelet count (PLT), platelecrit (PCT), mean platelet volume, white blood cells, platelet distribution width] were evaluated. Impedance Aggregometry was used to evaluate CR in the study. The results were given as the area under the curve. An adenosine diphosphate value higher than 46 U was taken as a resistance indicator. The relationship between blood tests and CR was investigated. Results: CR was detected in 33.3% (n=32) of 96 patients. PLT (295.7±12.4) and PCT values (0.3±0.01) were significantly higher in patients with resistance than those without resistance (p<0.005). Conclusion: This study shows that high PLT and PCT values can be used to predict CR.
Authors and Affiliations
Nihan Çarçak, Büşra Tuğba Özmen, Zeynep Selcen Dartıcı, Ufuk Emre, Özgür Kılıçkesmez
Keywords
Related Articles
- EP ID EP675988
- DOI 10.4274/imj.galenos.2019.92195
- Views 142
- Downloads 0
Comparative Evaluation of Three Different Treatment Approaches for Intertrochanteric Fracture in Advanced Age Patients
Introduction: Considering the general condition of elderly patients, it is important to treat intertrochanteric fracture along with early rehabilitation interventions. We compared the mortality and clinical outcomes amon...
Assessment of Nutritional Status of Hospitalised Geriatric Patients and its Relationship with Sarcopenia
Introduction: Sarcopenia and malnutrition are geriatric syndromes that reduce quality of life and muscle function in old age. This study aimed to evaluate the nutritional status of geriatric patients, determine the statu...
A Rare Case in Rheumatology Clinical Practice: Pachydermodactyly
Pachydermodactyly (PDD) is a benign, acquired digital fibromatosis characterized by asymptomatic and progressive swelling of periarticular soft tissue, and is usually seen in young men. The etiology of PDD is not fully u...
Evaluation of the Effect of NQO1 C609T (rs1800566) Gene Variations in Philadelphia-negative Myeloproliferative Neoplasms in Turkish Population
Introduction: Philadelphia-negative myeloproliferative neoplasm (MPN) is a hematopoietic stem cell disorder consisting of essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) associated...
A Case of Femoral Neuropathy Secondary to Iliopsoas Hematoma Due to Warfarin Intoxication
Warfarin is a widely used drug in patients with a high risk of thromboembolism in cardiovascular diseases. Serious complications can be encountered as a result of high side effect profile and narrow therapeutic window. I...