Clostridium difficile – emergent hospital flora

Journal Title: Revista de Medicină Militară - Year 2014, Vol 0, Issue 1

Abstract

Clostridium difficile (C. difficile) is a Gram-positive sporogenous bacillus strictly anaerobic, which in the last decade has became the most important anaerobic bacterium in nosocomial human pathology. Cl.dificile is the etiological agent of more than 20% of diarrhea postantibiotics, over 95% of pseudomembranous colitis and the first cause of nosocomial infectious diarrhea in adults. Although this bacterium usually colonizes the intestine of vertebrates (the normal microbiota), the toxinogenic strains (tcdA and tcdB) are pathogenic in the digestive tract. Given the excessive use of antibiotics and the increased spores resistance, it is possible an environment contamination, with strains which may already be resistant to antibiotics. The main causes of this infection are decreased resistance to antibiotic-induced colonization, contamination with a pathogenic strain of Cl.difficile, secretion of A and/or B toxins and deficient immune response. Due to the increasing worldwide incidence of infections with C. difficile on one hand and to the discovery of new ways of transmitting the infection according with some studies regarding the genetic diversity of bacterium strains on the other hand, a new approach is necessary for C. difficile related topics.

Authors and Affiliations

Gabriela Dumitrescu, Viorel Ordeanu, Simona Bicheru, Lucia Ionescu, Diana Popescu, Marius Necsulescu

Keywords

Related Articles

Evolution of mortality rates in ST elevation myocardial infarction

The purpose of this paper is to provide information about mortality rate in patients undergoing primary angioplasty for STEMI. Cardiovascular diseases lead to one third of the deaths worldwide, surpassing the mortality r...

Clinical aspects in implant fixed prosthodontics oral rehabilitation. Case report

Benzodiazepine overdose has various clinical manifestation, mainly regarding the central nervous system (CNS), cardiac and respiratory side effects, but rarely results in significant morbidity and mortality. Acute benzod...

Medical applications of the GC/MS method in the acute intoxication with dimethoate – clinical case

Mass spectrometry is a chemical analytical method of determining organic substances by comparing their mass spectrum with mass spectra found in system libraries. In the case of biological products, substances of interest...

Ethical considerations in sudden unexpected death in epilepsy (SUDEP)

Epilepsy is one of the world's oldest diseases. Social stigma, misunderstanding and thus, discrimination have surrounded patients and their families from the beginnings until nowadays. Approximatively up to 80% of epilep...

A case of acne fulminans

Background and aim: Acne fulminans is a rare and severe form of acne which usually appears in young men with a personal history of mild to moderate acne. It is characterized by a sudden onset with nodules and ulcerative...

Download PDF file
  • EP ID EP196320
  • DOI -
  • Views 90
  • Downloads 0

How To Cite

Gabriela Dumitrescu, Viorel Ordeanu, Simona Bicheru, Lucia Ionescu, Diana Popescu, Marius Necsulescu (2014). Clostridium difficile – emergent hospital flora. Revista de Medicină Militară, 0(1), 5-12. https://europub.co.uk/articles/-A-196320