Clostridium difficile infection a current therapeutic and epidemiological problem / Zakażenia Clostridium difficile – nadal aktualny problem leczniczy i epidemiologiczny
Journal Title: Przegląd Epidemiologiczny - Year 2017, Vol 71, Issue 2
Abstract
Clostridium difficile (CD) is the most common etiologic agent of antibiotic-associated diarrhea. The number of infections has increased dramatically in the last decade. Although the diseases caused by CD are mostly related to health care and antibiotic therapy, some are community-acquired cases. This article explains the pathogenesis of this microorganism, pointing to depletion of intestinal microflora diversity and the inadequate response of the immune system as an important factor predisposing the development of CD infection. Previous published studies have demonstrated an increased incidence of hipervirulent ribotype 027 in Poland and Europe and also the emergence of other ribotypes in various parts of Europe with increased potential for pathogenicity. A high percentage of CD strains, which were isolated in Poland demonstrated resistance to ciprofloxacin, imipenem, erythromycin and moxifloxacin and multidrug resistance. In addition, there was observed a trend to increase in the value of MIC for vancomycin and metronidazole. Factors that may affect the reduction of effectiveness in drug therapy include the sublethal doses achieved in the intestinal lumen, heterogenicity of resistance to metronidazole, the ability to form the biofilms, presence of protein, which repair damaged DNA, transformation of an antibiotic to inactive form and mutations leading to changes to the binding sites of vancomycin.
Authors and Affiliations
Aleksandra Mirecka
Keywords
Related Articles
- EP ID EP626340
- DOI -
- Views 94
- Downloads 0
Knowledge and beliefs in a selected group of parents of children aged 2 and less concerning preventive vaccination / Wiedza i przekonania wybranej grupy rodziców dzieci do 2. roku życia dotyczące szczepień ochronnych
OBJECTIVE: The objective of this research was to get to know the level of knowledge and beliefs concerning preventive vaccination among parents of children up to 2 years of age MATERIAL AND METHODS: The survey was carrie...
Evaluation of dental state in 6-year-old children from the Skierniewice region / Ocena stanu uzębienia u dzieci 6-letnich z rejonu Skierniewic
INTRODUCTION: Caries is a social disease and a serious problem, especially in the childhood. The effects of untreated caries can cause not only disorders of the stomatognathic system, but also have a negative impact on t...
Designer drugs – still a threat? / Narkotyki projektowane (dopalacze) czy nadal są zagrożeniem?
INTRODUCTION. In Poland, an increasing number of psychoactive substances are becoming prohibited by law as psychotropic or narcotic substances, or as new psychoactive substances (NPSs). Owing to the enormous technologica...
Wirusowe zapalenie wątroby typu A w Polsce w 2013 roku
CEL. Celem pracy jest ocena sytuacji epidemiologicznej wirusowego zapalenia wątroby typu A w Polsce w 2013 roku w porównaniu do lat ubiegłych. MATERIAŁ I METODY. Ocena została przeprowadzona na podstawie wyników analizy...
The prevalence of intestinal parasites in children in preschools and orphanages in the Warmia-Masuria province (North-Eastern Poland)
OBJECTIVE. A comparison of the prevalence of intestinal parasites (IP) in preschoolers and orphans in the Warmia-Masuria province (Poland). MATERIAL AND METHODS. Between 2003-2006 fecal samples and perianal swabs from 10...