Clostridium Difficile Infection - An Optimistic View
Journal Title: JURNALUL DE CHIRURGIE [JOURNAL of SURGERY] - Year 2017, Vol 13, Issue 2
Abstract
Background: Clostridium difficile infection (CDI) is one of the most common infectious complications affecting vulnerable patients, i.e., after surgery or immunosuppressive therapies, posing a significant risk in an oncological unit. Materials and methods: We analyzed data recovered from 164 cases of CDI during the period of 2014-2016 in the Regional Oncologic Institute Iasi, majority admitted in the surgical and hematological units. In all cases diagnostic was confirmed if stool samples tested positive for GDH and at least one of the toxins A or B. Results: The study shows a large population of elder patients (median age 64 years) with female dominance (54%). Out of 117 surgical cases 64% had surgical procedures on the gastro-intestinal tract. Although 20% of patients had equivocal symptoms from admission, the average interval (from admission) until first symptoms developed was 7 days. The confirmation of the diagnosis came in the next day/24h in 68% of cases, leading to initiation of efficient therapy. Although CDI is regarded as an antibiotic associated disease, our data revealed that only one third of patients received antibiotic treatment in the last 3 months. Among the risk factors that may have an influence over development of CDI, antisecretory therapy was delivered to 37% of cases. Epidemiology reports showed that less than 8% of patients had previous contact with other CDI confirmed case. Overall mortality was 4.87% and CDI related mortality was 0.85%. Conclusions: Even though CDI still poses a great threat during prolonged hospitalization and is especially dangerous in oncologic patients, the early recognition of disease onset and the easy access to diagnostic tests triggers an immediate course of treatment and decreases complication and the risk of spreading.
Authors and Affiliations
Tudor Frunză, Alexandru Rotundu, Ștefan Morărașu, Sorinel Luncă, Gabriel Dimofte
Keywords
Related Articles
- EP ID EP288505
- DOI 10.7438/1584-9341-13-2-4
- Views 118
- Downloads 0
Obesity is Linked with Inflammation-Evaluation of Subclinical Inflammatory Status in Obese Patients
Background: Obesity is one of the most important public health; it seems that inflammation is a pathogenic pathway between obesity and its associated comorbidities. The aim of the study was to evaluate the status of seru...
The Number of 7 Patient’s Clinical Analysis of Duodenal Neuroendocrine Neoplasms
Aim: The aim of this study was to report and analyze outcomes associated 7 patient’s in-hospital evaluation and investigate of the cliniopathological features diagnosis and treatment of duodenal neuroendocrine neoplasms....
Laparoscopic Right Colectomy from Up to Bottom
The laparoscopic right colectomy became a well-established technique in the surgical armamentarium of colorectal operations. It has well proved advantages: reduction in postoperative pain, time to return of bowel functio...
Multivisceral Resections in Advanced Gastric Cancer-Case Report
Background: Gastric cancer is an important cause of death in worldwide, despite the progress achieved through screening programs. Multivisceral resections are dictated by R0 resection gold, but also by the histopathologi...
Surgical Count Implementations in the Operating Rooms: An Example from Turkey
Aim: Although retained foreign bodies are a rare and preventable problem, it is one of the medical errors in surgery can have heavy medico-legal consequences. Retained sponges can cause significant morbidity, prolonged h...