Co - Deposition of Serum Amyloid P Component in mouse Brain following Chronic Inflammatory Mice
Journal Title: International Journal of Scientific Research and Management - Year 2015, Vol 3, Issue 8
Abstract
Background: Prolonged injection of casein results in systemic amyloidosis in mice with impaired hepatic functions due to excessive serum amyloid P component (SAP) deposition in liver, spleen, kidney and brain. Methods: We have carried out radiolabeling, fluorescence immuno staining and brain endothelial immune staining studies to source the serum amyloid P component (SAP) that present in the brain of the affected mice. Results: The experiments suggest that the systemic amyloidosis results in selective crossing of SAP proteins through b lood brain barrier (BBB). Injection of 125 I SAP to casein treated mice resulted in the accumulation of this proteins in the liver to the maximum extent and to about 20% (compared to liver) localization in the brain. Immuno histochemical studies also indica te that the abundance of SAP in the mice brain following chronic inflammatory condition. Conclusion: The present work provides a basis for investigation on the effect of chronic inflammation to the
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Asokan C
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- EP ID EP217442
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