COFFEE INTAKE REVERSES INSULIN RESISTANCE IN PREDIABETICS AND TYPE 2 DIABETICS: A PILOT STUDY IN ADULT WORKING NIGERIANS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 2
Abstract
The metabolic syndrome and its complications remain major contributors to the world’s morbidity and untimely deaths. Substantial evidence now seem to implicate components of the coffee matrix as incumbents in the management of type 2 diabetes mellitus. Caffeine, a non-selective adenosine receptor antagonist, and chlorogenic acid, a more important anti-oxidant, are the major bioactive constituent of coffee. Workers have observed recently that there may be dichotomous effects of acute versus chronic coffee consumption via adenosine A1- and A2A- receptor regulation on insulin signalling-, stress signalling- and chronic inflammatory- pathways to provide survival benefits. In this report, the effect of 2-3 cups of caffeinated coffee intake on blood glucose levels and blood pressure was investigated in 30 adult hypertensive diabetics of either sex and results were compared to controls. A daily intake of caffeinated coffee significantly (P < 0.05) normalised the glucose and blood pressure levels and restored a sense of well-being. It also significantly normalised the creatinine, urea and triglyceride levels. Also the dose of daily insulin administration was reduced by 3 of the patients and stopped by 5 of the patients; while the daily dose of metformin was stopped by 8 and reduced by 11 of the patients. Results show that caffeinated coffee intake increases insulin sensitivity and reverses insulin resistance in patients and deserves more attention on a larger sample size in the efforts against type 2 diabetes mellitus.
Authors and Affiliations
Dr. S. E. Oriaifo
Keywords
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