Cognition in adult migraineurs: An electrophysiological study
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2018, Vol 5, Issue 1
Abstract
Introduction Researches have shown that migraine causes clinically dormant brain lesions which can lead to gradual deterioration of cognitive functions in migraineursObjective The purpose of current study was to elucidate cognitive processing in migraine patients using auditory event related P300 potential as results of previous work in this field has not been very conclusiveMaterials and Methods 25 Migraine patients 8 males 17 females from neurology OPD of the associated hospital and 25 healthy age and gender matched controls were recruited for the study Study protocol included a thorough history taking followed by clinical neurological examination Migraine disability assessment MIDAS score was obtained from MIDAS questionnaire Participants were subjected to auditory P300 potential recording using oddball paradigm Responses to target stimuli were averaged and Latencies ms of the P300 peak and amplitudes microv of P300 were recordedResults P300 target stimulus latency in patients with Migraine was 34948 3850ms Mean SD and in healthy controls it was 30709 3718 Mean SD This was statistically significant Plt0001 No significant changes were observed in P300 amplitude between cases and control Neither P300 target stimulus latency nor P300 target stimulus amplitude showed any significant correlation with MIDAS scoreConclusion Decline in cognitive functions in patients with migraine does occur as seen with prolonged P300 latency when compared to healthy controls In time to come P300 may become an important tool for clinicians to assess certain aspects of cognitionKeywords Cognition P300 Event related potential MIDAS score Migraine
Authors and Affiliations
Pooja Ojha, Varun Malhotra, Nitin Pandey, Zeashan Zaidi
Keywords
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- EP ID EP475353
- DOI 10.18231/2394-2126.2018.0018
- Views 64
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