Cognitive dysfunction syndrome in senior canines
Journal Title: Revista MVZ Cordoba - Year 2010, Vol 15, Issue 3
Abstract
During their senior life, some dogs may show progressive changes in their normal behavior such as disorientation, decreased interaction with family members, irritability and excessive vocalization, among others. The non-specificity of these alterations has led to the erroneous belief that many of these behavioral modifications are, typical or “normal” signs of aging. However, this may be a reflection of a pathological process that causes progressive brain deterioration of the cognitive functions in senior dogs. Recently, a condition called Cognitive Dysfunction Syndrome in senior dogs or “dog Alzheimer’s disease” was described, due to its clinical and pathological similarities with the human disease. Affected animals develop morphological and functional changes in different areas of the brain, which probably leads to the appearance of changes associated with cognitive decline, i.e., decreased ability to gather, process, or retain information, and make decisions, which ends up causing deleterious effects on quality of life of affected patients by failing to function normally within their environment. Given the nonspecific clinical signs, medical history and behavioral tests have been considered as the main diagnostic tools to identify this syndrome. On the other hand, due to the fact that no etiopathological aspects have been fully established, the mechanisms used in the development of this neuropathology are still inconclusive, therefore, they are not many therapeutic strategies available, out of which Selegiline has been approved by the FDA.
Authors and Affiliations
Diana Gallego V, MV| Universidad Nacional de Colombia, Facultad de Medicina Veterinaria y de Zootecnia, Departamento de Ciencias para la Salud Animal, Sede Bogotá, Colombia., Judith Figueroa R, M. Sc| Universidad Nacional de Colombia, Facultad de Medicina Veterinaria y de Zootecnia, Departamento de Ciencias para la Salud Animal, Sede Bogotá, Colombia., Camilo Orozco S, Ph. D *| Universidad Nacional de Colombia, Facultad de Medicina Veterinaria y de Zootecnia, Departamento de Ciencias para la Salud Animal, Sede Bogotá, Colombia.Correspondencia: caorozcos@unal.edu.co
Keywords
Related Articles
- EP ID EP3179
- DOI -
- Views 345
- Downloads 18
Microbiota of Vibrio sp. in the hepatopancreas of cultured white pacific shrimp (Litopenaeus vannamei)
Objective. The present study aimed to investigate the presence of vibrios in the hepatopancreas of cultured shrimp. Materials and methods. Vibrios from the hepatopancreas of fifteen samples of five specimens each, of app...
Neospora caninum serostatus in dairy cattle of the Northern plains of Antioquia, Colombia
Objectives. To determine Neospora caninum seroprevalence in nonvaccinated dairy cattle from the Northern plains of Antioquia. Materials and methods. A cross-sectional study was conducted to determine the prevalence of ne...
ESTIMATION OF YIELD AND NUTRITIONAL VALUE OF BOBO MULLET (Joturus pichardi Poey, 1860) (Pisces: Mugilidae)
Objective. Evaluate the gutted and fillet yields of the besote (Joturus pichardi), as well as the nutritional quality and the degree of acceptance of its meat.Materials and Methods. Gutted and fillet yields were estimate...
Effect of sucrose in the production of cellulose by Gluconacetobacter xylinus in static culture
Objective. Determine the effect of sucrose on the productivity of BC by Gluconacetobacter xylinus IFO 13693 in static condition. Materials and methods. The synthesis of bacterial cellulose (BC) by Gluconacetobacter xylin...
Analysis of mdr1-1Δ mutation of MDR1 gene in the “Cimarron Uruguayo” dog
Objective. The aim of this paper is to analyze the frequency of the mdr1-1D mutation of the MDR1 gene in a dog sample of the Uruguayan Cimarron breed with the objective of increasing the knowledge of this breed’s genome....