Cognitive Impairment in Epilepsy: A Clinical Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 2
Abstract
Background: Patients with epilepsy have relatively higher risk for psychopathology and cognitive impairment. The research data indicate that the cognitive impairment and deterioration are due to associated brain damage and not attributable to epilepsy. The objective of the current study is to evaluate the cognitive functions in patients with adequate seizure control, without obvious brain damage and to compare with healthy first degree relatives. Method:This is a cross sectional case control study conducted in Father Muller Medical College Mangalore. A total of80 subjects, 40 patients attending the outpatient and inpatient facilities of the department of Neurology with a clinical diagnosis of idiopathic generalized tonic clonicepilepsy and 40 healthy age matched first degree relatives were evaluated. Tools used were Standardized Mini Mental Status Examination, Brief Cognitive Rating Scale, Trail Making Test-B and Digit Symbol Substitution Test for evaluation of cognitive functions. The various findings were statistically analyzedusing chi- square test,Student T test and ANOVA. Results: Patients with epilepsy showed significant cognitive impairment in TMT-B and DSST when compared with control.Patients with epilepsy committed more number of errors on these tests. Socio-demographic variables and clinical variables like age, education, socio-economic class, occupation and duration of epilepsy had significant correlation with worse cognitive functioning. Conclusions: Adult individuals with well controlled idiopathic generalized tonic clonic epilepsy without obvious structural brain damage have cognitive impairment compared to healthy first degree relatives.
Authors and Affiliations
Siddharth Shetty A, P John Mathai
Keywords
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