COMBINATION OF VENLAFAXINE AND DIAZEPAM ATTENUATES MARBLE-BURYING BEHAVIOR OF MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Obsessive-Compulsive Disorder (OCD) is an anxiety disorder featuring intrusive and troubling symptoms, which are perceived as the products of one’s own mind. This disorder is characterized by absurd, recurrent and persistent thoughts (obsessions) followed by certain stereotyped actions (compulsions). The OCD patients realize the irrational nature of thoughts and rituals, but feel helpless and hopeless about controlling them. Numerous genes modulating the serotonin and dopaminergic systems are thought to participate in the pathophysiology of OCD. Marble-burying behavior of mice has been employed to study anxiety disorders including obsessive–compulsive disorder (OCD). The aim of this study was to test the efficacy of venlafaxine and diazepam per se and in combination on marble-burying behavior of mice. In the present project a total of 126 male Swiss mice divided in 21 groups were employed. Venlafaxine (1 mg kg-1i.p.) per se as well as diazepam (0.25 mg kg-1i.p.) per se did not show any anti-compulsive activity. But, the combination comprising of ineffective doses of venlafaxine (1 mg kg-1i.p.) and diazepam (0.25 mg kg-1i.p.) showed significant anti-compulsive activity as reflected by inhibition of marble-burying behavior.
Authors and Affiliations
Milind Parle , Uday Gaikwad
Keywords
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