Combined Ethanol Leaf Extract of Sour Sop (Anonna Muricata) and Jackfruit (Artocarpus Heterophyllus) Leaves Amelioratesstreptozotocin Induced Type 2 Diabetes Mellitus In Wistar Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
Type 2 diabetes results from the inability of islet cells of the pancreas to produce insulin which regulates blood sugar. A lot of natural products have proven effective in the treatment of diabetes mellitus due to their rich phytochemical contents. Fifty-six(56) rats were given high fat diet (HFD) and 35mg/kg body weight of streptozotocin intraperitoneally to induce type 2 diabetes. The combined effects of A. muricata and A. heterophyllus on the blood glucose levels, amylase, liver function and the kidney function were analysed. The rats were treated with 100 and 200mg/kg body weight of combined ethanol extract of A. muricata and A. Heterophyllus, 200 mg/kg body weight ofethanol extract of A. muricata and A. Heterophyllusuncombined and 50 mg/kg body weight of metformin as a reference drug. The effects of combined ethanol leaf extract of A. muricata and Artocarpus heterophyllus on blood glucose level, liver function and kidney function of wistar albino rats were studied.The result showed an increase in plasma glucose levels and amylase activities of the albino rats (226.33 ± 12.85 mg/dl and 42.97±3.20 u/l respectively) after treatment with HFD and streptozotocin. Treatment of the albino rats with 100 and 200 mg/kg body weight of the combined ethanol leaf extract for 30 days led to a statistically significant decrease in plasma glucose levels of the animals 96.33±2.30 and 86.33±7.51 respectively. A significant decrease (p<0.05) was also observed in the AST, ALP and ALT activities of the diabetic after treatment for 30 days 127.33±5.03, 73.33 ± 6.80 and 73.33±6.81u/l respectively.The result of this research indicate that combined ethanol leaf extract of A. muricata and A. Heterophyllus has a synergetic effect on streptozotocin induced type 2 diabetes mellitus on wistar albino rats.
Authors and Affiliations
C. L Onuah, A. A Uwakwe, F. C Anacletus
Keywords
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