Commentary: Current Advances and Future Directions for CNS Delivery
Journal Title: The AAPS Journal - Year 2008, Vol 10, Issue 4
Abstract
Authors and Affiliations
Craig K. Svensson, Jean-Michel Scherrmann
Craig K. Svensson, Jean-Michel Scherrmann
Critical ligand binding reagent preparation/selection: When specificity depends on reagents
Throughout the life cycle of biopharmaceutical products, bioanalytical support is provided using ligand binding assays to measure the drug product for pharmacokinetic, pharmacodynamic, and immunogenicity studies. The spe...
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
In recent years mechanical systems have been developed that more closely mimic the full dynamic, physical and biochemical complexity of the GI Tract. The development of these complex systems raises the possibility that t...
Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery
Fentanyl free base was kindly supplied by Insys Therapeutics, Inc (Mundelein, IL), fentanyl citrate and sufentanil free base were obtained from Mallinckrodt Chemicals (St. Louis, MO). 1-Chlorobutane was purchased from Ac...
Biomarkers for Drug-Induced Renal Damage and Nephrotoxicity—An Overview for Applied Toxicology
The online version of this article (doi:10.1208/s12248-011-9301-x) contains supplementary material, which is available to authorized users.
Utility of a Bayesian Mathematical Model to Predict the Impact of Immunogenicity on Pharmacokinetics of Therapeutic Proteins
The impact of an anti-drug antibody (ADA) response on pharmacokinetic (PK) of a therapeutic protein (TP) requires an in-depth understanding of both PK parameters and ADA characteristics. The ADA and PK bioanalytical assa...