Common etiology and diagnosis of hyperbileacidemia
Journal Title: Journal of Clinical Hepatology - Year 2025, Vol 41, Issue 5
Abstract
Bile acids (BAs) are the main components of bile and serve as complex metabolic regulators and important signaling molecules, and they play a crucial role in fat metabolism. Hyperbileacidemia (HBA) is relatively common in clinical practice, but sometimes it is difficult to clarify its etiology. This article reviews the common diseases that cause HBA and the changes in the composition of the bile acid pool, so as to provide clear insights for the diagnosis of HBA.
Authors and Affiliations
Maoping LI, Kaizhong LUO
Changes in hepatic bile acid profile in a mouse model of metabolic-associated steatohepatitis induced by a high-fat, high-sugar, and high-cholesterol diet combined with carbon tetrachloride
[Objective] To compare the hepatic bile acid profile between a mouse model of metabolic-associated steatohepatitis (MASH) induced by a high-fat, high-sugar, and high-cholesterol diet combined with intraperitoneal inj...
Experience in eliminating the mother-to-child transmission of hepatitis B virus in China
Reducing the mother-to-child transmission of hepatitis B virus (HBV) is crucial for achieving HBV elimination. Launched in July 2015 at the Great Hall of the People in Beijing, China, the “Zero Hepatitis B Mother-to-...
Pancreatic cancer neuroecology: Current status, mechanisms, and prospect from multi-dimensional perspectives
Pancreatic cancer is characterized by nerve invasion and a high mortality rate, and its pathological process depends on the complex interaction network between tumor and the nervous system. Based on the concept of “panc...
Diagnostic value of miR-128-3p, SIRT1, and AMPK in patients with type 2 diabetes mellitus comorbid with nonalcoholic fatty liver disease
[Objective] To investigate the expression levels of miR-128-3p, SIRT1, and AMPK in the peripheral blood of patients with type 2 diabetes mellitus (T2DM) comorbid with nonalcoholic fatty liver disease (NAFLD), as w...
Role of neuroimmune communication via the gut-brain axis in the pathogenesis of hepatic encephalopathy
Hepatic encephalopathy (HE) is a common severe liver disease syndrome in clinical practice and is one of the critical and severe diseases in internal medicine, and more than half of liver failure patients diagnosed wi...