COMPARATIV EEFFECTS OF SPIRONOLACTONE AND COMBINATION WITH FUROSEMIDE OF ASCITES FLUID AND BLOOD ELECTROLYTE IN CIRRHOSIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: This study was to compare the effects of spironolactone and combination with furosemide on blood electrolyte levels and ascites fluid in patients with cirrhosis. [G1]Â Methods: This research was undertaken with prospectively experimental analysis on a limited population in DR. M Djamil General National Hospital, Padang. We include 11 patients with spironolactone used and 13 patients with combination spironolactone-furosemide utilized.Results: The percentage of patients who experienced blood electrolyte disturbances with the use of spironolactone was hyponatremia 72.72%, hypernatremia 0%, hypokalemia 45.45%, hyperkalemia 9.09%, hypocalcemia 9.09%, hypercalcemia 18.18%. The percentage of blood electrolyte disturbances on the use of a combination of spironolactone-furosemide hyponatremia was 100%, hypernatremia 0%, hypokalemia 23.07%, hyperkalemia 7.69%, hypocalcemia 15.38%, hypercalcemia 0%. A reduction in body weight and abdominal circumference patients before and after use of spironolactone-furosemide combination is significant (p=0.000). [G2]Â [G3]Â Conclusion: The effects of spironolactone and combination with furosemide to the blood electrolyte levels in this study showed that the highest percentage of impaired blood electrolyte is hyponatremia and hypocalcemia. Spironolactone-furosemide combination therapy for weight-loss and abdominal circumference better than the single use of spironolactone.Â
Authors and Affiliations
Zamharira Muslim, Helmi Arifin, Nasrul Zubir
Keywords
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