Comparative Acute Oral Toxicity Study of Verona Anti-BPH with Verona Max in Mice
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Objective: Benign Prostate hyperplasia (BPH) is hyperplasia of prostate gland and age related diseases in men. 20%-60% men have BPH with the age of 40 to 60 years. The cause is not very well researched however the pharmacological and surgical current treatments have numerous toxic effects on quality of life. Natural medicines are known for its safety as compare to pharmacological choice of medicines. By considering this fact, current experimental study was established to compare and assess the acute oral toxicity of the Verona Anti-PBH with Verona Max in NMRI strain of mice on animal model. Methodology: NMRI mice were obtained for experimental purpose from animal house facility of Herbion Pvt. Ltd. Constant environmental conditions were 25 ± 1 °C with R.H 52 - 61% with 12 hours dark and light cycle. As per desire, food and water were available. Animals were divided into three different groups including two treatment and control group. Treatment group including Verona Anti-BPH and Verona Max however control group were on water. Animal’s age were 6-8 weeks and average body weight were 25-35 g however cage cards were used for identifications between the groups. Mice were treated orally using gastric gavage with doses (1 or 5g/kg) of test product for 14 days and observed daily. Results: The Verona anti-BPH and Verona Max did not cause any sign of ill health and acute toxicity in mice at the given doses of 1 or 5 g/kg. No hair loss, color loss, heart rate (chest expansion and retraction), writhing, stretching and fecal abnormality was observed. No remarkable change in the behavior and no mortality was observed. Conclusion: The present study evaluated that Verona anti-BPH and Verona Max extract is potentially safe and no acute oral toxicity has found.
Authors and Affiliations
Hina Rehman
Keywords
Related Articles
- EP ID EP605047
- DOI -
- Views 184
- Downloads 0
Depression and Associated Risk Factors Among Medical and Allied Health Sciences Students of Southern Punjab, Pakistan
Aim: Depression is diagnosed mostly in medical and allied health sciences students and affects their study performance. The study was conducted to obtain the prevalence of depression of the students of a developing area....
Formulation and Assesment of Clomifene Citrate Tablet by Direct Compression Method
The problem of Infertility is developing in western societies and also in eastern societies, some researches have examined the utilization of drug for widespread treatments of infertility. Clomifene citrate is the first-...
Phytochemical Analysis and Tyrosinase Inhibitory Potential of Cassia absus (Seeds)
Objective: To perform phytochemical analysis and investigation of the tyrosinase inhibitory activity of Cassia absus seeds. Methods: Various extracts of Cassia absus seed were prepared such as ethanolic extract, n-hexane...
Research paper Formulation and Evaluation of Sustained Release Matrix Tablets of Furosemide Using Different Polymers
Objective: The aim of the present research study was to develop and evaluate sustained release matrix tablets of 100 mg furosemide using direct compression method. Method: Eighteen formulations were prepared using differ...
Single Blind, Placebo Control Phase III Study of Insty Granules to Evaluate its Efficacy and Safety
Aims and objectives: Cold symptoms are well recognized as sore throat, nasal congestion and clogging, sneezing, coughing, headache and fatigue. This clinical trial was conducted to evaluate the efficacy and safety of Ins...