Comparative Analysis of Anti Versus Probiotic in Patients with Irritable Bowel Syndrome
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 7
Abstract
Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with high prevalence. It imposes a significant economic burden to the health-care system worldwide. Earlier IBS was thought to be a disease hard to categorize, difficult to diagnose and impossible to treat, but over the years, the pathophysiology and clinical paradigm of IBS have been well elucidated so are the therapeutic options and diagnostic strategies. Objective: In our study, we tried to analyze the efficacy of antibiotic (rifaximin) versus probiotic (VSL#3) in alleviating symptoms of IBS. Materials and Methods: Comparative efficacy of anti-biotic versus pro-biotic was assessed in 220 IBS patients with regard to improvement in global IBS symptoms. The study was conducted in the postgraduate Department of Medicine, Government Medical College, Srinagar, from February 2012 to September 2013 and all the enrolled patients had given informed consent before conducting this study. Results: There was a significant improvement in global IBS symptoms in both the groups even after switchover of drugs in both the cohorts. The safety profile of both drugs was the same.
Authors and Affiliations
Vinod Mitla, Surinder Sharma, Syed Arshad Mustafa, Mohd. Ismail
Keywords
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