Comparative Analysis of Oral Clonidin against Oral Midazolam as Premedication in Adults

Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 6

Abstract

Introduction: The comparison was made between the clonidine 200 ug and midazolam 15 mg to check the clinical efficacy in respect to the sedative, attenuation of hemodynamics, anxiolytic and antisialogogue response in adult patient undergoing general anesthesia. Material and Methods: Total of 100 patients were included in the study, included patient belong ASA 1-2 physcial status and the age group of 20 – 50 years. Males and females, both genders were included in the study. Of the total 100 patients; they were randomly divided into two groups with 50 patients in each group. Patients included in the group 1 were given Oral clonidine 200 ug, 90 mins prior to the surgery. Patients included in the group 2 were given oral midazolam 15 mg, 90 mins prior to the surgery. General anesthesia with thiopentone sodium, vecuronium, fentanyl, oxygen, nitrous oxide and sevoflurane were given to all the patients. Five point sedation score was used to assess the patient’s level of sedation. We recorded the baseline values before medication and 90 mins after medication. After intubation period of 1, 5 and 10 mins the hemodynamic parameters were recorded. Results: The extent of sedation was seen in the patient given Midazolam as compared to the clonidine pretreated patients. In the clonidine group we see the antisialogogue effect. In the clonidine group all the haemodynamic parameters were well maintained throughout the period of study. Conclusion: There was significant attenuation of pressor response to laryngoscopy and intubation in the clonidine group as compared to midazolam therefore drug of choice for premedication.

Authors and Affiliations

Ram Nandan Prasad

Keywords

Related Articles

A Prospective Randomized Study on the Efficacy of Interpleural Analgesia in Reducing Post Operative Pain and Parenteral Analgesic Requirement in Patients Undergoing Upper Abdominal Surgery

Administration of local anesthetics into the pleural space provides rapid onset and long duration of analgesia upper abdomen surgeries without respiratory depression as seen with opioids.in this study we attempt to find...

A Comparative Study between Continuous Epidural Infusion and Continuous Femoral Nerve Block for Post-Operative Pain Relief in Total Knee Replacement Surgeries

Background: Postoperative pain management in TKR is of imperative importance. Epidural analgesia though considered as a standard technique in postoperative pain management in TKR it was commonly associated with unwanted...

Effect of Addition of Dexmedetomidine to Ropivacaine in Lumbar Plexus Block for Post Operative Pain Management in Neck of Femur Fracture

Introduction: The incidence of femoral neck fractures, one of the most common traumatic injuries in elderly patients increases continuously among the ageing population. Anaesthetic management of NOF is either spinal or g...

Supraclavicular Versus Infraclavicular Approach of Subclavian Vein Cannulation in ICU Patients

Background: Subclavian vein is generally preferred in ICU for central venous access. Infraclavicular and supraclavicular approaches are the two techniques of subclavian venous catheterisation. Infraclavicular approach to...

Comparison of Low Dose Fentanyl with Low Dose Dexamethasone as an Adjuvant to 0.5% Bupivacaine in Supraclavicular Block via Multipoint Injection Technique under Sonographic Guidance

Background: To see effect of low dose fentanyl vs low dose dexamethasone in ultrasound guided supraclavicular block via multipoint injection technique. Methods: This double blinded randomized controlled study was carried...

Download PDF file
  • EP ID EP541418
  • DOI 10.21088/ijaa.2349.8471.5618.20
  • Views 67
  • Downloads 0

How To Cite

Ram Nandan Prasad (2018). Comparative Analysis of Oral Clonidin against Oral Midazolam as Premedication in Adults. Indian Journal of Anesthesia and Analgesia, 5(6), 1004-1008. https://europub.co.uk/articles/-A-541418