Comparative Antioxidative and Antidiabetic Activities of Ficus Carica Pulp, Peel and Leaf and their Correlation with Phytochemical Contents
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2020, Vol 4, Issue 2
Abstract
Objective: Globally, there is a growing interest in the use of medicinal plants because of their potential therapeutic benefits as complementary and alternative therapies. The present study is focused on the In-vitro evaluation of antioxidative and antidiabetic activities of the peel, pulp, and leaves parts of Ficus carica, commonly called fig plant. Methods: The dried parts (peel, pulp, and leaves) of the studied plant were powdered and extracted in 70% methanol for the estimation of total phenolic contents, antioxidative and α-amylase inhibitory activities. The possible antioxidant profiles of the methanolic extracts were measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging assay while antidiabetic property of different parts of the fig plant was evaluated through inhibition of α-amylase. Results: The methanolic extract of leaves showed highest potential to inhibit DPPH free radicals compared to all other parts with resultant IC50 values of pulp = 83.918 > peel = 41.846 >leaf = 17.407 µg/mL that correlate strongly with its high phenolic contents [leaf = 353.5 ˃ peel = 187.5 ˃ pulp = 62.5 (mg gallic acid equivalents/gm of dried extract)]. Anti- α-amylase activity showed that leaf extract contained highest inhibition to inhibit this enzyme among the three parts (IC50 value of pulp = 1.237 > peel = 0.899 ˃ leaf = 0.896 µg/mL). Conclusion: Fig leaves, peel and pulp can be utilized as effective remedy to control abnormal carbohydrate metabolism associated with diabetes and hyperglycemia, however further molecular studies are needed to explore the additional mechanism(s)
Authors and Affiliations
Iffat Ara*, Syeda Hina Naqvi, Najeeb Ur Rehman and Mohammad Moiz Qureshi
Keywords
Related Articles
- EP ID EP746334
- DOI 10.23880/oajpr-16000197
- Views 22
- Downloads 0
Pharmacological Action of Taxifolin: A Review
Taxifolin is a potent plant flavonoid. The most sources of taxifolin include onions, tamarind seeds, French maritime bark and milk thistle and are also commercially available in semisynthetic forms. It was within the mi...
In-silico Study for African Plants with Possible Beta-Cell Regeneration Effect through Inhibition of DYRK1A
Background: The continuous destruction of normal insulin-producing pancreatic beta cells is a contributing factor in all common forms of diabetes, due to insufficient production of insulin, especially in type 1 diabetes...
Drug Therapy Problems among Patients with both Cardiovascular Diseases and Diabetes Mellitus in a Sub-Saharan African Referral Hospital
Background: Patients with both type 2 diabetes mellitus and cardiovascular disease receive multiple medications but there are limited studies on drug therapy problems among them in Sub-Saharan Africa. Objective: To det...
Marine Actinomycetes the Past, the Present and the Future
In the field of exploring new natural sources for biologically active products with economic importance, the marine environment draws particular attention due to the noticeable diversity and extreme conditions; it is we...
The Evolving Definition of Comparative Effectiveness Research: Lessons for Researchers Planning and Designing a Clinical Development Program
Among the many challenges that must be overcome in successfully developing a novel drug treatment is to understand and prepare evidence that will ultimately be required by regulators and reimbursement authorities. Payers...