Comparative assessment of clinical-paraclinical manifestations of rotavirus infection versus genotypical variety in infants
Journal Title: One Health & Risk Management - Year 2021, Vol 2, Issue 2
Abstract
Introduction. RVI (rotavirus infection) is the most common cause of dehydration in infants and young children. The implementation of the sentinel surveillance of RVI in infants from 2008 in the Republic of Moldova demonstrated the high rate of this infection (40.0%), being an argument in recommending the antirotaviral immunization in children within the National Immunization Program. Material and methods. The study enrolled 193 children with acute diarrheal disease, included in the sentinel supervision (2012-2016) and treated in the Unit for Acute Diarrheal Diseases at Children’s Clinical Hospital no. 1. The biological material was examined by serological enzyme-linked immunosorbent assay (ELISA) and genotyping, revealed by polymerase chain reaction (PCR). Results. The rotavirus infection was confirmed in 193 infants, of which 121 children were not vaccinated against RVI, and 72 were immunized. Depending on the genotypes encountered before and after vaccination, it was found that G9P [8], G3P[8], G4P[8] were detected before vaccination, although postvaccine prevailed G2P[4], G4P[8]. In addition, the incidence of RVI is decreasing and the disease evolution is much better. Conclusions. This article reflects the evolution of the genotypic properties of rotaviruses and the clinical-paraclinical particularities of RVI in infants, highlighting the importance of the implementation of antiretroviral immunization in children within the National Immunization Program in the Republic of Moldova.
Authors and Affiliations
Ala DONOS, Tatiana ALSALIEM, Constantin SPINU, Ninel REVENCO, Valentin TUREA, Ion MIHU, Radu COJOCARU, Stela GHEORGHITA, Igor SPINU, Albina-Mihaela ILIEV, Luminita SUVEICA
Keywords
Related Articles
- EP ID EP693654
- DOI 10.38045/ohrm.2021.2.06
- Views 114
- Downloads 0
E-health: Evaluation of the implementation of the Personal Electronic Health Record by family doctors in Greece
Introduction Ε-health (eH) is a basic component of current health care provision. The cornerstone of eH is the electronic health record (EHR) system. Material and methods The purpose of this survey is to assess the Greek...
The efficacy of direct-acting antiviral therapy in patients with chronic hepatitis C
Introduction. Viral hepatitis C (HCV) is a significant global health problem. The risk of developing chronic HCV is up to 80% of patients, of whom 10-20% can develop liver cirrhosis or hepatocellular carcinoma which can...
Left ventricular remodeling patterns in children with metabolic syndrome
Introduction. Pathological left ventricular (LV) remodeling in children with metabolic syndrome (MS) is associated with a significant increase in cardiometabolic risk. However, data regarding the prevalence of LV remodel...
Parasitic nematodes in potatoes of different varieties and their interrelations with some arthropods
Introduction. Potato (Solanum tuberosum L.) is susceptible to infestation with an associated complex of different species of parasitic and saprophytic nematodes, bacteria, fungi, and arthropods, which diminish the qualit...
Retrospective study on the prevalence of COVID-19 confirmed cases and evidence of gender bias in Libya
Introduction. To stop SARS-CoV-2 from spreading, it's crucial to have a solid understanding of the baseline characteristics of demographic variables, clinical symptoms, and comorbidity so that quarantining and testing pr...